Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

Wound healing properties of Eucheuma cottonii extracts in Sprague-Dawley rats

Samaneh Ghasemi Fard1, Rosalina Tan Roslan Tan1, Ajwad Awad Mohammed2, Goh Yong Meng2, Sharifah Kharidah Syed Muhamad1, Karim Alwan AL-Jashamy3 and Suhaila Mohamed1,4*
1Faculty of Food Science and Technology, University Putra Malaysia, UPM 43400 Serdang, Selangor, Malaysia. 2Faculty of Veterinary Medicine, University Putra Malaysia, UPM 43400 Serdang, Selangor, Malaysia. 3Faculty of Health and Life Sciences (FHLS), Management and Science University (MSU), Jln Equestrian 13/52, Off Persiaran Sukan, Sek.13, 40100 Shah Alam, Selangor, Malaysia. 4Institute of BioScience, University Putra Malaysia, UPM 43400, Serdang, Selangor, Malaysia.
Email: [email protected]

  •  Accepted: 20 January 2011
  •  Published: 23 November 2011


Wounds are unavoidable events of life and arise due to agents that induce stress or injury. Wound has been a menace the world over and healing is a survival mechanism and represents an adaptation to the maintenance of normal anatomical structure and function. The objective of this study was to evaluate the potential wound healing properties of ethanolic and aqueous extracts of Eucheuma cottonii. A two centimeter diameter of skin excision wound was made on normal rats. Treatment with honey (100 mg/kg body weight) was used as positive control and untreated rats as the negative control. Inflammation and proliferation phases of wound healing including wound contraction, re-epithelization and granulation tissue development were monitored. This study showed both seaweed extracts increased the rate of wound contraction compared with the positive and negative control groups. Ethanolic extract of E. cottonii was more effective than the aqueous extract by 20% (P<0.05). Histopathological findings showed the ethanolic extracts enhanced epithelization and tissue granulation significantly compared with both control groups. E. cottonii possesses several antioxidant compounds, which may be responsible for the accelerated wound healing. The present study demonstrated that these seaweed extracts accelerated healing better if not comparable with honey.


Key words: Seaweed (Eucheuma cottonii), wound healing, histopathology.