Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

Bioactive chalcone from Indigofera pulchra

Musa, A. M.1*, Aliyu, A. B.2, Abdullahi, M. I.1, Yaro, A. H.3, Magaji, M. G.4, Hassan, H. S.1 and Iliya, I.5
1Department of Pharmaceutical and Medicinal Chemistry, Ahmadu Bello University, Zaria, Kaduna State, Nigeria. 2Department of Chemistry, Ahmadu Bello University, Zaria, Kaduna State, Nigeria. 3Department of Pharmacology, Bayero University, Kano, Kano State, Nigeria. 4Department of Pharmacology and Therapeutics, Ahmadu Bello University, Zaria, Kaduna State, Nigeria. 5National Institute for Pharmaceutical Research and Development, Idu, Abuja, Nigeria.
Email: [email protected]

  •  Accepted: 30 August 2011
  •  Published: 16 October 2011


Extensive phytochemical investigations using silica gel column chromatography, gel filtration and preparative thin layer chromatography (TLC) led to the isolation of 2’ 4’- dihydroxy-4-prenyloxy chalcone from the methanol extract of Indigofera pulchra. The structure of this compound was elucidated with the help of NMR and mass spectroscopy. The analgesic effect of the compound was studied using acetic acid induced writhing and hot plate tests in mice. The compound isolated showed significant analgesic activity in acetic acid induced writhing test but no activity in the hot plate test, suggesting that it posses peripheral analgesic activity. To the best of our knowledge, this is the first report of the isolation of this compound.


Key words: Prenyloxychalcone, analgesic activity, Indigofera pulchra, 1 and 2D NMR.