Ten known compounds, four flavonoids Agathisflavone (1), 7”-methyl-agathisflavone (2), amentoflavone (3), apigenine (4), three steroids sitosterol (5), stigmasterol (6), campesterol (7) besides three terpenoids, lupeol (8), friedeline (9) and α-tocoferol (10) were isolated from leaves of Ouratea parviflora (Ochnaceae). The structures were proposed on basis of 1D- and 2D-NMR, mass spectra analysis and comparison with literature data.Agathisflavone, 7”-methyl-agathisflavone and lupeol presented antiviral activities against HSV-1 with 50% effective dose (ED50) values of 11.2, 25.8 and 47.5 μg/ml, respectively. Regarding anti-HSV-2 activity, agathisflavone and 7”-methyl-agathisflavone presented ED50values of 2.8 and 1.5, respectively, whereas the lupeol did not have anti-HSV-2 activity.
Key words: Ouratea parviflora, antiviral, biflavonoids.
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