Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3843

Full Length Research Paper

Proposed active compounds from Ouratea parviflora

Marcelo F. de Araújo1*, Claudiana B. dos Santos1, Jéssica F. Cavalcanti2, Fernanda S. Pereira2, Gabriella S. Mendes2, Alceni A. Werle3, Maria Teresa V. Romanos2 and Mário G. de Carvalho1
1Department of Chemistry,Laboratory of Natural Products Chemistry (LQPN), ICE, Universidade Federal Rural do Rio de Janeiro, BR 465 KM.07,23890-000, Seropédica-RJ, Brazil. 2Department of Virology, Laboratory Experimental of Antiviral and Cytotoxic Drugs, Instituteof Microbiology Paulo Góes, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro,RJ, Brazil. 3Department of Chemistry, ICEB-Universidade Federal de Ouro Preto (UFOP), 35400-000, Ouro Preto-MG, Brazil.
Email: [email protected]

  •  Accepted: 04 February 2011
  •  Published: 18 June 2011

Abstract

Ten known compounds, four flavonoids Agathisflavone (1), 7”-methyl-agathisflavone (2), amentoflavone (3), apigenine (4), three steroids sitosterol (5), stigmasterol (6), campesterol (7) besides three terpenoids, lupeol (8), friedeline (9) and α-tocoferol (10) were isolated from leaves of Ouratea parviflora (Ochnaceae). The structures were proposed on basis of 1D- and 2D-NMR, mass spectra analysis and comparison with literature data.Agathisflavone, 7”-methyl-agathisflavone and lupeol presented antiviral activities against HSV-1 with 50% effective dose (ED50) values of 11.2, 25.8 and 47.5 μg/ml, respectively. Regarding anti-HSV-2 activity, agathisflavone and 7”-methyl-agathisflavone presented ED50values of 2.8 and 1.5, respectively, whereas the lupeol did not have anti-HSV-2 activity.

 

Key words: Ouratea parviflora, antiviral, biflavonoids.

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