Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3693

Full Length Research Paper

Screenings of In-vitro antimicrobial, cytotoxic and anti-inflammatory activity of crude methanolic extracts of Crinum latifolium (Leaves)

Md. Abdur Rahman*
  • Md. Abdur Rahman*
  • Department of Pharmacy, Noakhali Science and Technology University, Sonapur-3814, Noakhali, Bangladesh.
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Md. Saddam Hussain
  • Md. Saddam Hussain
  • Department of Pharmacy, Noakhali Science and Technology University, Sonapur-3814, Noakhali, Bangladesh.
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Md. Shalahuddin Millat
  • Md. Shalahuddin Millat
  • Department of Pharmacy, Noakhali Science and Technology University, Sonapur-3814, Noakhali, Bangladesh.
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Mithun Chandra Ray
  • Mithun Chandra Ray
  • Department of Pharmacy, Noakhali Science and Technology University, Sonapur-3814, Noakhali, Bangladesh.
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Mohammad Tohidul Amin
  • Mohammad Tohidul Amin
  • Department of Pharmacy, Noakhali Science and Technology University, Sonapur-3814, Noakhali, Bangladesh.
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Md. Mizanur Rahman Moghal
  • Md. Mizanur Rahman Moghal
  • Department of Pharmacy, Mawlana Bhashani Science and Technology University, Santosh, Tangail-1902, Bangladesh.
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  •  Received: 21 July 2016
  •  Accepted: 09 September 2016
  •  Published: 03 October 2016

Abstract

Crude methanolic extracts of Crinum latifolium plant (Leaves) was assayed to identify various pharmacological properties. Antimicrobial potential of crude methanolic extracts of C. latifolium was accomplished by most commonly used disc diffusion method against a wide range of Gram positive (+ve) and Gram negative(-ve) bacteria. Extracts showed slight antimicrobial activity against Gram positive (+ve) bacteria while surprisingly showed significant antimicrobial activity against Gram negative (-ve) bacteria Escherichia coli. In contrast to vincristine sulphate, the crude methanolic, n-hexane soluble, petroleum ether soluble and chloroform soluble extracts showed slight to moderate cytotoxic properties with LC50 value of 7.06, 48.978, 242.83 and 153.93 µg/ml respectively. Plant extract showed significant (P<0.05) anti-inflammatory properties, that is, 16.21 and 20.55%10 mg/ml for hypotonic solution and heat induced condition respectively. So, this plant extract demands further research for revealing all its potency to have new safe drug for the entire respective field of medical science.

Key words: Crinum latifolium, zone of inhibition, brine shrimp lethality bioassay, anti-inflammatory.