Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3778

Full Length Research Paper

Anti-respiratory syncytial virus (RSV) activity of timosaponin A-III from the rhizomes of Anemarrhena asphodeloides

Ui Joung Youn, Ji-Eun Jang, Joo-Won Nam, Yoo Jin Lee, Young Min Son, Hyun Ji Shin, Ah-Reum Han, Jun Chang and Eun-Kyoung Seo*
The Center for Cell Signaling and Drug Discovery Research, College of Pharmacy, Ewha Womans University, Seoul 120-750, Korea.
Email: [email protected]

  •  Accepted: 22 February 2010
  •  Published: 04 April 2011

Abstract

Two known steroidal saponins, timosaponin A-III (1) and anemarsaponin B (2) were isolated from the BuOH fraction of the rhizomes of Anemarrhena asphodeloides Bunge (Liliaceae) together with the xanthone derivatives, mangiferin (3) and neomangiferin (4). Structures of the isolates were identified using 1D and 2D NMR techniques and by comparison with the published values. Timosaponin A-III (1) exhibited potent inhibitory effects on the respiratory syncytial virus (RSV), with an IC50 value of 1.00 µM.

 

Key words: Liliaceae, Anemarrhena asphodeloides, timosaponin A-III, respiratory syncytial virus (RSV).