Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

Effects of Lonicera japonica Thunb. on dextran sulfate sodium-induced experimental colitis in mice

Keyong Ho Lee1, Kyung-Sook Whang2 and Ki - Hyeong Rhee3*
1Kolon Life Science Inc., Yongin City, 446-797, Korea. 2Department of Microbiol and Nano Materials, Mokwon University, Daejeon, 302-729, Korea. 2College of Industrial Sciences, Kongju National University, Yesan 340-702, Korea.
Email: [email protected]

  •  Accepted: 10 June 2011
  •  Published: 16 October 2011


We investigated the effects of buthanol (BuOH) extracts of Lonicera japonica on dextran sulfate sodium (DSS)-inducedq mice colitis. Body weight, histological indices such as crypt injury and inflammation score, biochemical factor such as serum amyloid (SAA) and MPO level data were evaluated. BuOH extracts of L. japonica reduced the crypt injury and inflammation score and showed markedly greater more decreases of the SAA and MPO levels relative to the 5-ASA group. In addition, BuOH extracts will reduce the level of IL-6 which is stimulated by a lipopolysaccharide (LPS) in the HT-29 cell line in vitro. Therefore, BuOH extracts of L. japonicamay be useful as a potential inhibitor for preventing inflammatory bowel disease in humans.


Key words: Lonicera japonica, dextran sulfate sodium, inflammatory bowel disease.