Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3834

Full Length Research Paper

Flavonoids and an alkaloid from Zanthoxylum naranjillo and their in vitro evaluation on the reproductive fitness of Schistosoma mansoni

Talita A. da Silva1, Camila Y. Henrique1, Caio G. Braguine1, Ubirajara O. Gonçalves1, Lizandra G. Magalhães1, Vanderlei Rodrigues2, Jairo K. Bastos3, Márcio L. A. Silva1, Wilson R. Cunha1, Ana H. Januário1 and Patrícia M. Pauletti1*
1Núcleo de Pesquisa em Ciências Exatas e Tecnológicas, Universidade de Franca, Franca, São Paulo, 14404-600, Brazil. 2Departamento de Bioquímica e Imunologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, 14040-903, Brazil. 3Departamento de Ciências Farmacêuticas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, 14040-903, Brazil.
Email: [email protected]

  •  Accepted: 13 August 2012
  •  Published: 26 September 2012

Abstract

The chemical investigation of n-butanol fraction (BF) from the leaves of Zanthoxylum naranjillo (Rutaceae) by open column and preparative HPLC resulted in the isolation of magnoflorine (1), apigenin-6-C-β-d-glucopyranoside (2) and apigenin-8-C-β-d-glucopyranoside (3). This is the first time that the presence of compounds 1 to 3 in Z. naranjillo has been reported. Compounds 1 to 3 and BF were screened in vitro againstSchistosoma mansoni adult worms. The results indicated that BF and compound 3 were able to separate coupled S. mansoni adult worms.

 

Key words: Zanthoxylum naranjillo, Rutaceae, antischistosomal activity.

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