It has long been known that herbs and their extracts have antimicrobial activities. Heracleumlasiopetalum Boiss., Satureja bachtiarica Bunge., Thymus daenensis Celak., Echiophoraplatyloba L., Dracocephalum multicaule Benth., Kelussia odoratissima Mozaff. and Achilleakellalensis Boiss. are Iranian endemic plant species that have been traditionally used as medicinal herbs and spices in different regions of Iran especially Central Zagross. Seven ethanolic extracts of endemic medicinal herbs and one extract of native medicinal herb (Stachys lavandulifolia Vahl.) collected from Chaharmahal va Bakhtiari province of Iran were assayed for the in vitro antifungal activity against Candida albicans (ATCC1023), using agar dilution methods. Most of the extracts showed relatively high anti-Candida activity against the tested fungi with the diameter of inhibition zone ranging between 8 and 17 mm. The extracts ofS. bachtiarica and T. daenensis exhibited high inhibitory effect against C. albicans. The extracts of S. bachtiarica and T. daenensis were characterized using HPLC, the major components of S. bachtiarica and T. daenensis were carvacrol and thymol, respectively. The minimum inhibitory concentration (MIC) values for active extract range between 25 and 50 µg/ml. In conclusion, it can be said that the extract of some of the Iranian endemic medicinal plants (S. bachtiarica and T. daenensis) could be used as natural anti-Candida.