The effect of ethanol leaf extract of Gnetum africanum was studied in albino rats induced with benign prostatic hyperplasia. The animals (36) were randomly grouped into six with six rats in each group. Testosterone and oestradiol every other day for 28 days was used to induce hyperplasia. The test groups (2 - 4) were treated with 200, 400 and 800 mg/kg body weight of extract for another 28 days. Group 5 was given the standard drug while group 6 served as negative control. At the end of the treatment period, the rats were sacrificed under anesthesia and blood samples collected for biochemical analysis. The results showed that in the animals exposed to the inducing agents increased significantly (p <0.05) in activity of MDA, ACP and PSA levels whereas there was a significant (p >0.05) decrease in the activities of GR, CAT and SOD as compared with the normal control. However, treatment with ethanol leaf extract of G. africanum showed significant (p >0.05) increase in the activities of the antioxidant enzymes and significant (p >0.05) decrease in the level of MDA, ACP and PSA in a dose dependent manner as comparable to the normal control. These findings are indication that the extract of G. africanum has potential remedial effects on benign prostatic hyperplasia.
Key words: Gnetum africanum, oxidative stress, antioxidants, chemopotential, prostate hyperplasia.
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