Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

Effect of ethanol leaf extract of Gnetum africanum on testosterone and oestradiol induced benign prostatic hyperplasia

EBENYI Lilian N.
  • EBENYI Lilian N.
  • Department of Biotechnology, Faculty of Science, Ebonyi State University, P. M. B. 043, Abakaliki, Ebonyi State, Nigeria.
  • Google Scholar
YONGABI Kenneth A.
  • YONGABI Kenneth A.
  • Department of Biotechnology, Faculty of Science, Ebonyi State University, P. M. B. 043, Abakaliki, Ebonyi State, Nigeria.
  • Google Scholar
ALI Fredrick U.
  • ALI Fredrick U.
  • Department of Biotechnology, Faculty of Science, Ebonyi State University, P. M. B. 043, Abakaliki, Ebonyi State, Nigeria.
  • Google Scholar
OMINYI Mathias C
  • OMINYI Mathias C
  • Department of Biotechnology, Faculty of Science, Ebonyi State University, P. M. B. 043, Abakaliki, Ebonyi State, Nigeria.
  • Google Scholar
ANYANWU Blessing
  • ANYANWU Blessing
  • Department of Biotechnology, Faculty of Science, Ebonyi State University, P. M. B. 043, Abakaliki, Ebonyi State, Nigeria.
  • Google Scholar
OGBANSHI Moses E.
  • OGBANSHI Moses E.
  • Department of Biochemistry, Faculty of Science, Ebonyi State University, Abakaliki, Ebonyi State, Nigeria.
  • Google Scholar


  •  Received: 28 December 2019
  •  Accepted: 14 April 2020
  •  Published: 31 July 2020

References

Akpanabiatu MI, Umoh IB, Uoh FE, Udosen EO (2006). Effect of leaf extracts on some rats serum enzymes of clinical significance: Recent progress in medicinal plant. Biopharmaceutical 14:297- 304.

 

Alcaraz A, Hammerer P, Tubaro A, Schröder FH, Castro R (2009). Is there evidence of a relationship between benign prostatic hyperplasia and prostate cancer? Findings of a literature review. European Urology 55(4):864-873.
Crossref

 

Ali F, Assanta MA, Robert C (2011). Gnetumafricanum: A Wild Food Plant from the African Forest with Many Nutritional and Medicinal Purposes. Journal of Medicinal Food 14:1289-1297.
Crossref

 

Anand P, Kunnumakkara AB, Kunnumakara AB, Sundaram C, Harikumar KB, Tharakan ST, Lai OS, Sung B, Aggarwal BB (2008). Cancer is a preventable disease that requires major lifestyle changes. Pharmaceutical Research 25(9):2097-2116.
Crossref

 

Andren O, Fall K, Franzen L, Andersson SO, Johansson JE, Rubin MA (2006). How well does the Gleason score predict prostate cancer death? A 20-year follow up of a population based cohort in Sweden. Journal of Urology175:1337-1340.
Crossref

 

Bartsch G, Rittmaster RS, Klocker H (2002).Dihydrotestosterone and the concept of 5alpha-reductase inhibition in human benign prostatic hyperplasia. World Journal Urology 19:413-425.
Crossref

 

Besong M, Samalang P, Abia C (2001). Commercialization as an incentive and threat for Gnetumspp (eru) in Cameroon. Proceedings of A Workshop on Incentive Measures for Sustainable Use and Conservation of Agro-Biodiversity 14:69-72.

 

Bowe L, Michelle GC, Claude W (2000) Phylogeny of Seed plants based on all three Genomic Compartments: Extant gymnosperms are monophyletic and Gnetales, closest relatives are Conifers. Proceedings of the National Academy of Sciences 97:4092-4097.
Crossref

 

Bushman W (2009). Etiology, epidemiology and natural history of benign prostatic hyperplasia. Urology of Clinical North American 36:403-415.
Crossref

 

Chindong M (2011). Reporting Science in Africa. Agfax.

 

De Nunzio C, Aronson W, Freedland SJ, Giovannucci E, Parsons JK (2012). The correlation between metabolic syndrome and prostatic diseases. European Urology 61(3):560-570.
Crossref

 

Ebenyi LN, Ibiam UA, Aja PM (2012). Effects of Alliums sativum extract on paracetamol - induced hepatotoxicity in albino rats. International Research Journal of Biochemistry and Bioinformatics 2(5):93-97.
Crossref

 

Edet UU, Ehiabhi OS, Ogunwande IA, Walker TM, Schmidt JM, Setzer WN, Ogunbinu AO, Ekundayo O (2005). Analyses of the volatile constituents and antimicrobial activities of Gongronemalatifolium (Benth and Gnetumafricanum L). Journal of Essential Oil Bearing Plants 8:324-329.
Crossref

 

Enam RMN, Joseph MA, Harlow SD, Wei JT (2014).Risk factors for lower urinary tract symptoms in a population-based sample of African-American men. American Journal of Epidemiology 117:206-212.

 

Esraa A,Nakaya K, Murata E (2014). Benign prostatic hyperplasia (BPH) can be a progressive disease if left untreated. American Journal of Epidemiology 121:20-12.

 

Hillman U (1971). Acid phosphatase based on enzyme kinetic method. Journal of Essential Plants 4:211-719.

 

National Cancer Institute (2018). Analyses of the volatile constituents and antimicrobial activities of Gongronemalatifolium (Benth and Gnetumafricanum L). Journal of Essential Oil Bearing Plants 4:331-319.

 

Robert JM, Breyer-Brandwijk MG (2011).The Medicinal and Poisonous Plants of Southern and Eastern Africa.2nd ed. Livingstone, London, p. 1241.

 

Soltis N, Ali S, Nickel JC, Taylor JM, James SA, Cooney KA, Doerr KM (2002). Light microscopic and stereological analysis of the normal human prostate and of benign prostatic hyperplasia. Journal of Urology 122:487-491.
Crossref

 

Suzuki K, Koike H, Matsui H, Ono Y, Hasumi M, Nakazato H, Okugi H, Sekine Y, Oki K, Ito K, Amamoto T, Fakubori Y, Korukawa K, Yamanaka H (2002). A soyIsoflavone, induces glutathione peroxidase in the human prostate cancer cell lines. International Journal of Cancer 99(6):846-852.
Crossref

 

Tekwe C, Ndam N, Nkefor JP (2003). Gnetum domestication for Livelihood Improvement and Conservation. World Agroforestry Congress.

 

Udoh FV (2007). The Effects of Gnetumafricanum leaf extracts on some biochemical indices and endocrine functions in albino rats. Postgraduate School, University of Calabar, Nigeria, p. 6210.

 

Wasserman NF (2006). Benign Prostatic Hyperplasia: A review and ultrasound classification. Radiology Clinical North American 44:689-710.
Crossref

 

Wein T, Linuna M, Ali Z, Nakaya K (2007). Regulation of vascular differentiation in leaf primordial during the rhythmic growth of Gnetumafricanum. Journal of Botany 14:202-203.