Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3778

Full Length Research Paper

Comparative in vitro trypanocidal activities of water and methanol extracts of three parts of Khaya senegalensis on Trypanosoma evansi

A. A. Adeiza1*, H. K. Makeri1 and M. Mohammed2
1Department of Animal Health and Husbandry, College of Agriculture and Animal Science, Ahmadu Bello University, P. M. B. 2134, Mando Road, Kaduna, Nigeria. 2Department of Chemistry, College of Agriculture and Animal Science, Ahmadu Bello University, P. M. B. 2134, Mando Road, Kaduna, Nigeria.
Email: [email protected]

  •  Accepted: 11 June 2010
  •  Published: 30 September 2013

Abstract

A comparative phytochemical and in vitro studies of water and methanolic extracts of three different parts of Khaya senegalensis, a plant used by herbalists in Nigeria to treat helminthiasis and other ailments revealed the presence of alkaloids, carbohydrates, tannins, saponins, flavonoids, terpenes sugars, cardiac glycosides and phlobatannins. At a dose of 20 mg/ml the water extract (leaf, stem bark and root) immobilised Trypanosoma evansi the most at 25 min while the methanol extract showed the most activity in the stem bark at 30 min. The results obtained with these crude extracts showed that K. senegalensis is a potential source of trypanocidal drug/chemical leads.

 

Key words: Khaya senegalensis, Trypanosoma evansi, trypanocidal activity, mando road, in vitro, water, methanolic.