Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3843

Full Length Research Paper

Physiological and histological impact of Azadirachta indica (neem) leaves extract in a rat model of cisplatin-induced hepato and nephrotoxicity

Doaa Ezz-Din1, Mohamed S. Gabry1, Abdel Razik H. Farrag2 and Ahmed E. Abdel Moneim1*
1Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, Egypt. 2Department of Pathology, Medical Research Division, National Research Centre, Cairo, Egypt.
Email: [email protected]

  •  Accepted: 22 August 2011
  •  Published: 23 October 2011

Abstract

This study investigated the protective effect of Azadirachta indica (neem) leaves against cisplatin-induced hepato and nephrotoxicity. Neem leaves showed significant protection as evidenced by the decrease of elevated serum alanine aminotransferase, aspartate aminotransferase, gamma glutamyl transpeptidase, alkaline phosphatase, total bilirubin, creatinine, uric acid and urea. This improvement of physiological function was associated with high protection against histopathological injury induced by cisplatin on liver and kidney. These results suggest that neem leaves pre, co and post-treatment can prevent the hepato and nephrotoxicity induced by cisplatin.

 

Key words: Cisplatin, Azadirachta indica, liver, kidney, rats.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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