Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3753

Full Length Research Paper

Anti-platelet activity of methanolic extract of Grewia asiatica L. leaves and Terminalla chebula Retz. fruits

M. Zia-Ul-Haq1*, Shakir Ahmad Shahid2, Sagheer Ahmed3, Shakeel Ahmad4, Mughal Qayum5 and Inamullah Khan6
1Research Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Karachi, Karachi-75270, Pakistan. 2Department of Chemistry, University of Sargodha, Sargodha-40100, Pakistan. 3Institute of Pharmaceutical Sciences, Kohat University of Science and Technology, Kohat-2600, Pakistan. 4Department of Agronomy, Bahauddin Zakariya University, Multan-60800, Pakistan. 5Department of Pharmacy, Anbar Campus, Abdul Wali Khan University, Mardan-23200, Pakistan. 6Department of Pharmacy, University of Peshawar, Peshawar-25120, Pakistan.
Email: [email protected]

  •  Accepted: 06 January 2012
  •  Published: 16 March 2012

Abstract

There is resurgent interest in exploring the anti-platelet activity of medicinal plant extracts because these are cost effective, easily available form of indigenous resources and are comparable to synthetic blood thinners in this prospective. Current investigation has been carried out to assess the anti-platelet activity of crude methanolic extracts of Grewia asiatica L. leaves and Terminalia chebula Retz. fruits. Both crude extracts exhibited potent platelet aggregation inhibition activity in a dose-dependent manner at concentration range (1 to 10 mg/ml). This preliminary screening suggests that G. asiatica L. leaves and T. chebulaRetz fruits crude extract can be considered as herbal treatment for disease associated with blood clotting.

 

Key words: Anti-platelet activity, Grewia asiatica L., Terminalia chebula Retz.