Abstract

The study was aimed to evaluate the analgesic and anti-inflammatory activity (by both in-vitro and in-vivo) of both chloroform and methanol root extracts of Syzygium alternifolium(wt) Walp. Methods used for the studies are In-vitro measurement of 5-lipoxygenase inhibition and in-vivo measurement of rat paw edema and ear edema in rats, acetic acid induced writhing response and heat induced pain. Our findings clearly indicate that S. alternifolium chloroform root extract showed 5-LOX inhibition activity similar with the standard drug, Zileutin. In in-vivo anti-inflammatory studies, S. alternifolium chloroform root extract exhibited better anti-inflammatory activity in comparison to the S. alternifoliummethanolic root extract. Similar results were observed in the acetic acid induced writhing model and radiant heat induce model. Hence, it was concluded that S. alternifoliumchloroform root extract exhibited more degree of efficacy in comparison to the S. alternifolium methanolic extract and good in-vitro and in-vivo anti-inflammatory effect.

Key words: Syzygium alternifolium, 5-lipoxygenase (5-LOX), analgesia, inflammation.