Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3843

Full Length Research Paper

Effect of the extract of Hypericum perforatum on neurodevelopment of regions related to pain control and convulsion

Leandro Véspoli Campos
  • Leandro Véspoli Campos
  • Centro de Biologia da Reprodução – Universidade Federal de Juiz de Fora, Juiz de Fora, MG, CEP: 36036-900, Brazil.
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Martha de Oliveira Guerra
  • Martha de Oliveira Guerra
  • Centro de Biologia da Reprodução – Universidade Federal de Juiz de Fora, Juiz de Fora, MG, CEP: 36036-900, Brazil.
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Vera Maria Peters
  • Vera Maria Peters
  • Centro de Biologia da Reprodução – Universidade Federal de Juiz de Fora, Juiz de Fora, MG, CEP: 36036-900, Brazil.
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Rita de Cássia da Silveira e Sá
  • Rita de Cássia da Silveira e Sá
  • Departamento de Fisiologia e Patologia - CCS – Universidade Federal da Paraíba, João Pessoa, PB, CEP: 58051-900, Brazil.
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  •  Received: 20 November 2016
  •  Accepted: 27 January 2017
  •  Published: 10 February 2017

Abstract

Hypericum perforatum (HP) is well-known by the population of the world as herb with antidepressant effect. Its various components, such as hypericin and hyperforin, provide many other effects for this plant, for example, antinociceptive and anticonvulsant. The aim of this work was to determine whether HP administration during pregnancy can cause changes in neurodevelopment related to pain control and seizures in rats (F1). For this, Wistar rats received oral doses of HP at 36, 72 and 144 mg/kg throughout pregnancy. Tests to evaluate the antinociceptive and anticonvulsant activity of HP were performed in adult F1 rats, which showed a decrease of both responses, suggesting therefore that HP exposition during pregnancy causes changes in neurodevelopment of brain regions related to pain control and seizures in rats.

Key words: Hypericum perforatum, antinociceptive effect, convulsion, neurodevelopment, reprogramming, ontogeny, epigenetic.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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