Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

Protective effects of ginger (Zingiber officinale Roscoe) against cadmium chloride-induced oxidative stress in the blood of rats

Atef, M. M. Attia*
  • Atef, M. M. Attia*
  • Biophysical laboratory, Biochemistry Department, Division of Genetic Engineering and Biotechnology, National Research Center, Dokki, Cairo, Egypt.
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Fatma, A. A. Ibrahim
  • Fatma, A. A. Ibrahim
  • Biophysical laboratory, Biochemistry Department, Division of Genetic Engineering and Biotechnology, National Research Center, Dokki, Cairo, Egypt.
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Noha, A. Abd EL-Latif
  • Noha, A. Abd EL-Latif
  • Biophysical laboratory, Biochemistry Department, Division of Genetic Engineering and Biotechnology, National Research Center, Dokki, Cairo, Egypt.
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Samir, W. Aziz
  • Samir, W. Aziz
  • Biophysical laboratory, Biochemistry Department, Division of Genetic Engineering and Biotechnology, National Research Center, Dokki, Cairo, Egypt.
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Sherif A. Abdelmottaleb Moussa
  • Sherif A. Abdelmottaleb Moussa
  • Biophysical laboratory, Biochemistry Department, Division of Genetic Engineering and Biotechnology, National Research Center, Dokki, Cairo, Egypt. Department of Physics, College of Science, Al-Imam Muhammad Ibn Saud Islamic University, P. O. Box 90950, Riyadh 11623, Saudi Arabia.
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  •  Received: 05 August 2014
  •  Accepted: 14 October 2014
  •  Published: 17 October 2014

Abstract

Cadmium is a heavy metal of wide occupational and environmental contamination. In recent years, however, cadmium has been implicated in the pathogenesis of several clinical disorders. Generation of oxidative stress is one of the plausible mechanisms for cadmium-induced diseases. The aim of the study was to investigate the effect of ginger on oxidative stress in rats exposed to cadmium (Cd) of a dose (10 mg/kg b.w.). Ginger was administered orally (500 mg/kg b.w.). After 26 days, significant increases in methemoglobin% (metHb%), carboxyhemoglobin% (HbCO%), glutathione peroxidase (GPx) activity, malondialdehyde (MDA) concentration and hemolysis%  were observed in cadmium exposed rats compared to control group (P < 0.05), while glutathione-S-transferase (GST), glutathione reductase (GR) and glucose-6-phosphate dehydrogenase (G6PD) showed insignificant changes. Cadmium treatment of rats caused a significant decrease in oxyhemoglobin% (HbO2%) and total blood hemoglobin (Hb) concentration (P < 0.05). Ginger treatment of cadmium exposed rats significantly lowered metHb% (P < 0.05), while significantly increased HbO2% (P < 0.05) and total Hb concentration (P < 0.01), compared to cadmium alone group. Also ginger treatment significantly increased GPx and G6PD activities of cadmium exposed rats compared to cadmium alone group (P < 0.05). The treatment of Cd-exposed animals with ginger lowered MDA concentration and hemolysis% by 20% and 17%, respectively. From these findings it can be concluded that ginger is a strong antioxidant plant that protects the blood of rats against the adverse harmful effects of cadmium chloride exposure as well as cadmium chloride-induced oxidative stress.

 

Key words: Cadmium, ginger, oxidative stress, erythrocytes, hemolysis, hemoglobin derivatives, rats.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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