Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3793

Full Length Research Paper

In vitro Antimicrobial activities of chloroformic, hexane and ethanolic extracts of Citrullus lanatus var. citroides (Wild melon)

Loiy Elsir Ahmed Hassan1, Hasnah Mohd Sirat2, Sakina M. Ahemd Yagi1, Waleed S. Koko3, and Siddig Ibrahim Abdelwahab4*
1Department of Botany, Faculty of Science, University of Khartoum, Khartoum, Sudan 2Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, Skudai, Johor, Malaysia. 3Medicinal and Aromatic Plant Research Institute, Khartoum, Sudan. 4Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Email: [email protected]

  •  Accepted: 22 December 2010
  •  Published: 18 April 2011

Abstract

To test the antimicrobial activities of  crude chloroform, hexane and ethanol extracts of leaves, stem, fruits and seeds from Citrullus lanatus var. citroides (CL) against bacteria (Escherichia coliStaphylococcus aureusPseudomonas aeruginosaBacillus subtilis andProteus vulgaris) and fungi (Aspergillus nigar and Candida albican). Antimicrobial properties of CL were tested using cup-plate diffusion method and disc diffusion. Analysis of the data revealed that, the chloroform extract of the fruit exhibited the highest antibacterial activity. It showed antibacterial activity against S. aureus: 36 mm, B. subtilis; 38 mm, E. coli; 37 mm,P. valgaris; 23 mm and P. aerguinosa; 19 mm.  The ethanolic extract of the fruit pulp and stem showed the highest antifungal activity on C. albican (41 mm). A. nigar was very sensitive to the chloroform extract of the seed (37 mm) and the ethanolic extract of the leaves (37 mm). Results were compared concurrently to standard drugs; clotrimazole and gentamicin. Based on the current findings, it can be concluded that this plant has antimicrobial activity, which is as potent as standard antimicrobial drugs against certain microorganisms.

 

Key words: Citrullus lanatus var. citroides, antimicrobial, medicinal plants.