Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3676

Full Length Research Paper

Antioxidant, anti-inflammatory and anticancer activities of methanolic extracts from Jatropha curcas Linn.

Ehsan Oskoueian1, Norhani Abdullah2*, Wan Zuhainis Saad1, Abdul Rahman Omar3, Syahida Ahmad2, Wen Bin Kuan2, Nor Azlina Zolkifli2, Rudi Hendra2 and Yin Wan Ho3
1Department of Microbiology, Faculty of Biotechnology and Biomolecular sciences, Universiti Putra Malaysia, Selangor, Malaysia. 2Department of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia. 3Institute of Bioscience, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.
Email: [email protected]

  • Article Number - 5FB390415867
  • Vol.5(1), pp. 49-57 , January 2011
  •  Accepted: 25 October 2010
  •  Published: 04 January 2011

Abstract

A comprehensive study on the phytochemical contents and biological activities of the methanolic extract from different parts of Jatropha curcas Linn. was conducted. The extracts of different plant parts contained various levels of phenolics, flavonoids and saponins. Latex and leaf extracts showed the highest antioxidant activity. Root and latex extracts inhibited the inducible nitric oxide synthase in macrophages RAW 264.7, comparable to L-Nitro-Arginine Methyl Ester (L-NAME), indicating appreciable anti-inflammatory activities. Cytotoxicity assay results indicated the anticancer therapeutic property of the root extract against human colon adenocarcinoma (HT-29) cell line but its cytotoxic effect on human hepatocyte (Chang cell) was high.

 

Key words: Jatropha curcas Linn., phytochemicals, antioxidant, anti-inflammatory, cytotoxicity.

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