Abstract

To investigate the effects of alprostadil on the change of hemodynamic parameters of intrinsic artery of kidney in the early stage of renal inadequacy in diabetic nephropathy and the application value of color doppler ultrasonagraphy. Thirty normal subjects were in control group, while fifty subjects were in the treatment group who were diagnosed as being in the early stage of rental inadequacy in diabetic nephropathy. Color doppler ultrasonography was used to examine the segmental rental artery (SRA), interlobular artery (IRA) and arcuate rental cortex artery (ARA), meanwhile observation and analyses were made towards its peak systolic blood flow velocity (Vsmax), end diastolic blood flow velocity (Vdmin) and pulse index (RI). Compared with the control group, Vdmin and Vsmax of SRA, ARA and IRA was reduced markedly before Alprostadil treatment, but RI rised remarkably (P<0.05). Vsmax of SRA and Vdmin of SRA and ARA were up evidently (P<0.05), but RI decreased significantly (P<0.05). Color doppler ultrasonography is of value in assessing renal inadequacy of diabetic nephropathy. Alprostadil plays an active role in improving renal bloodstream in the early stage of renal inadequacy in diabetic nephropathy, and RI can be served as a sensitive index to evaluate its effect.

Key words: Diabeticnephropathy, color doppler ultrasonography, alprostadil, intrinsic artery of kidney, resistance index.