Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

Astragalus polysaccharides induced gene expression profiling of intraepithelial lymphocytes in immune-suppressed mice

Lu Cheng1, He Xiaojuan1, Xiao Cheng2, Guo Yuming1, Zha Qinglin1, Liu Yuanyan3, Liu Zhenli4, Chen Shilin5 and Lu Aiping1*
1Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China. 2Sino-Japan Friendship Hospital, Beijing, China. 3School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China. 4Institute of Basic theory, China Academy of Chinese Medical Sciences, Dongzhimen, Beijing, China. 5Institute of Medicinal Plant Development, China Academy of Medical Sciences, Beijing, China.
Email: [email protected]

  •  Accepted: 22 February 2012
  •  Published: 30 March 2012

Abstract

Astragalus polysaccharides (APS) possess a variety of immunomodulatory activities, but the regulation on mucosal immunity is not fully understood. In this study, immune suppression in mice was induced with cyclophosphamide treatment and APS was used as an intervention and was administrated at dosages of 3 g/kg (APS HD) and 1.5 g/kg (APS LD). Intraepithelial lymphocytes (IELs) were isolated from the intestines. The mRNA expressions from IELs in different groups of mice were detected using gene expression microarray to explore the gene expression profile of IELs, and what are the unique pathways related to low and high dosage of APS.

 

Key words: Astragalus polysaccharides, mucosal immunity, intraepithelial lymphocytes, gene expression.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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