Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3785

Full Length Research Paper

Phytochemical screening and evaluation of cytotoxic, antimicrobial and cardiovascular effects of Gomphrena globosa L. (Amaranthaceae)

Daniel Dias Rufino Arcanjo1*, Ingrid Virgínia de Oliveira Sena4, Adonai Carvalho Medeiros de Albuquerque1, Bernardo Melo Neto2, Lorena Citó Lopes Resende Santana2, Náiguel Castelo Branco Silva3, Maria Marilza Moita1, Maria das Graças Freire de Medeiros2, Maria José dos Santos Soares3, Nilza Campos de Andrade4 and Antônia Maria das Graças Lopes Citó4
1Department of Biophysics and Physiology, Federal University of Piauí, Brazil. 2Department of Biochemistry and Pharmacology, Federal University of Piauí, Brazil. 3Department of Veterinary Morphophysiology, Federal University of Piauí, Brazil. 4Department of Chemistry, Federal University of Piauí, Brazil.
Email: [email protected]

  •  Accepted: 19 January 2011
  •  Published: 18 May 2011

Abstract

Gomphrena globosa L. (Amaranthaceae) is used in folk medicine in the treatment of high blood pressure and other diseases. To confirm this popular use, ethanol extract from leaves of G. globosa L. was prepared by maceration and analyzed by some phytochemical and biological assays, including cardiovascular activity. The phytochemical screeningdetected the presence of saponins, alkaloids, reducing sugars and coumarins. The extract did not induce either lethality in the brine shrimp (Artemia salina Leach) bioassay orantimicrobial activity. The negative results for cytotoxic and antimicrobial assays indicated possible low cytotoxicity to the extract. In other hand, it promoted a hypotensive activity by significant reduction in arterial blood pressure without change heart rate, confirming the therapeutic use as antihypertensive for this plant.

 

Key words: Gomphrena, Amaranthaceae, antihypertensive, cytotoxicity, Artemia salina.