Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3737

Full Length Research Paper

Antimicrobial and anticholinesterase activities of the essential oils isolated from Salvia dicroantha Stapf., Salvia verticillata L. subsp. amasiaca (Freyn and Bornm.) Bornm. and Salvia wiedemannii Boiss.

Buket Kunduhoglu1*, Mine Kurkcuoglu2, Mehmet Emin Duru3 and Kemal Husnu Can Baser2
1Department of Biology, Faculty of Science and Arts, EskiÅŸehir Osmangazi University, 26480 EskiÅŸehir, Turkey. 2Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, 26470 EskiÅŸehir, Turkey. 3Department of Chemistry, Faculty of Science and Arts, MuÄŸla University, 48121 MuÄŸla, Turkey.
Email: [email protected]

  •  Accepted: 21 October 2011
  •  Published: 09 December 2011


In this study, the essential oil compositions and antimicrobial and anticholinesterase activities of three Turkish endemic Salvia species were investigated. The gas chromatography(GC) and gas chromatography - mass spectrometry (GC-MS) analysis of the essential oils obtained from Salvia dicroantha, Salvia verticillata subsp. amasiaca, and Salvia wiedemanniishowed that the major constituents were caryophyllene oxide (22.4%), Germacrene D (36.6%), and α-pinene (36.2%), respectively. All essential oils exhibited antimicrobial activity against tested Gram-positive and Gram-negative bacteria, and test yeast strains. The minimum inhibitory concentrations (MICs) of oils ranged from 12.5 to 50.0 µl/ml. Additionally, essential oils were more active than standard antifungals, inhibiting test strains of yeasts such as Candida albicans, Candida glabrata, and Saccharomyces cerevisiae. At 400 µM concentration, the essential oil of S. wiedemannii had moderate acetylcholinesterase (55.95±2.01%), and butyrylcholinesterase (50.97±3.12%) inhibitory activity, while other two species no activity against both enzymes.


Key words: Salvia dicroanthaSalvia verticillata subsp. amasiacaSalvia wiedemannii, essential oil, antimicrobial activity, anticholinesterase activity, minimum inhibitory concentrations (MICs).