Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

Effects of salidroside on the protection of diabetic encephalopathy and improvement of abilities of learning and memory in rat

Heng Zhao1, Yang Zhang2, Bo Liu3, Ke Meng4 and Chunyan Wang1*
1The First Hospital of Jilin University, Changchun130021, China. 2School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China. 3The Third Hospital of Jilin University, Changchun 130033, China. 4School of Public Health, Jilin University, Changchun 130021, China.
Email: [email protected]

  •  Accepted: 30 August 2011
  •  Published: 23 November 2011


Salidroside, a phenol glycoside isolated from Rhodiola rosea, has been reported to have many pharmacological properties, among which are the protective effects against neuronal death. Salidroside has the best pharmacological effects at the concentration of 50 mg/kg Salidroside (po) for rodents. A diabetic encephalopathy rat model has been generated in this research. After treating with salidroside, the blood glucose reduced and body weight increased in rats. Morris water maze test indicated that salidroside could improve memory and learning ability, because it can protect the brain, promote neurons growth and balance neuron growth factors. Salidroside can also keep biochemistry markers and morphology normal in hippocampus. All these suggest that salidroside may be a potential drug for the treatment of diabetic encephalopathy and other nervous system diseases.


Key words: Diabetes mellitus, salidroside, hippocampus, Morris water maze tests, oxidative stress, signal pathway.