Abstract

To investigate the effects of baicalin on arrhythmia, induced by aconitine poisoning sixty acute patients with aconitine poisoning were studied and randomly enrolled into two groups: the experimental group and the control group, according to the number given to the patient when he/she was admitted to the hospital. Odd numbers were used as experimental groups, while even-numbered patients were used as control. Patients from the control group were treated using conventional methods. Patients from the experimental group were treated with baicalin as the sole antiarrhythmic medication. At the same time, the reasons for taking the aconite roots, the clinical features, management, and possible treatment mechanism were noted. The clinical outcome of the baicalin on the patients in the experimental group was significantly better than that in the control group. For patients in the experimental group, flutter in all patients disappeared within 15 min and sinus bradycardia disappeared within 12 h; all clinical symptoms improved after 25.2 ± 9.7 min and blood pressure reached the normal level within 30 min. For patients in the control group, it took more than 24 h for arrhythmia to disappear, 1764.1 ± 664.4 min for the clinical symptoms to be alleviated and over 27 h (p < 0.01) for the blood pressure to reach the normal level. Our study indicated that baicalin injection was efficacious in treating aconitine poisoning induced arrhythmia.

Key words: Aconitine, poisoning, baicalin, arrhythmia.