Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3672

Full Length Research Paper

One-pot synthesis of potential antioxidant agents, 3-carboxylate coumarin derivatives

Lijuan Han
  • Lijuan Han
  • Dr. Chunyan Yan, College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
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Bing Huang
  • Bing Huang
  • Dr. Chunyan Yan, College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
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Zhiwei Xiong
  • Zhiwei Xiong
  • Dr. Chunyan Yan, College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
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Chunyan Yan*
  • Chunyan Yan*
  • Dr. Chunyan Yan, College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
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  •  Received: 12 January 2015
  •  Accepted: 16 February 2015
  •  Published: 03 April 2015

Abstract

A simple and efficient route to synthesize 3-carboxylate coumarin derivatives through three-component one-pot reaction in a single step has been recommended. This method provides a direct and rapid access to get 3-carboxylate coumarin derivatives. The structures of these synthetic products were identified and the antioxidant activities were tested by inhibiting DPPH· and ·OH radicals capacities. The data suggested that 2H-1-penzopyran-3-carboxylicacid, 7,8-dihydroxy-2-oxo-, ethyl ester showed excellent activity in reducing both DPPH· and ·OH radicals in concentration-dependent manners with IC50 value of 83.1 μg/ml in DPPH· radicals and less than 0.12 mg/ml in the ·OH scavenging activity.

 

Key words: 3-Carboxylate coumarin, synthesis, antioxidant activity.