A simple and efficient route to synthesize 3-carboxylate coumarin derivatives through three-component one-pot reaction in a single step has been recommended. This method provides a direct and rapid access to get 3-carboxylate coumarin derivatives. The structures of these synthetic products were identified and the antioxidant activities were tested by inhibiting DPPH· and ·OH radicals capacities. The data suggested that 2H-1-penzopyran-3-carboxylicacid, 7,8-dihydroxy-2-oxo-, ethyl ester showed excellent activity in reducing both DPPH· and ·OH radicals in concentration-dependent manners with IC50 value of 83.1 μg/ml in DPPH· radicals and less than 0.12 mg/ml in the ·OH scavenging activity.
Key words: 3-Carboxylate coumarin, synthesis, antioxidant activity.
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