Abstract

The present investigation was designed to determine the antidiabetic activity of the methanol: ethyl acetate (1:9) extract of root of Peltophorum pterocarpum on alloxan and glucose induced diabetic mouse model. The extract was given intraperitoneally at a dose of 200 and 300 mg/kg body weight and the hypoglycemic effects was compared with standard drug vincristine sulphate, a standard drug. The extract reduced blood glucose level in both diabetic model and at 300 mg/kg dose, the test sample showed better activity. The extract was also subjected to brine shrimp lethality bioassay and phytochemical screening test. LC₅₀ value of the extract was 28.25 µg/ml and for standard drug vincristine sulphate it was 14.55 µg/ml. Preliminary phytochemical screening of the extract revealed the presence of different types of compounds including flavonoids and steroids. Our results suggest that root of P. pterocarpum demonstrated promising antidiabetic activity with low cytotoxicity that substantiated its ethnomedicinal use and may provide new molecules for the treatment of diabetes.

Key words: Antidiabetic, alloxan, brine shrimp, phytochemical, Peltophorum pterocarpum.