Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

Antimicrobial and immunomodulatory effects of Aloe vera peel extract

Ka Hee Kwon1, Min Ki Hong1, Sun Young Hwang1, Bo Youn Moon1, Sook Shin1, Jin Hong Baek2 and Yong Ho Park1*
1Department of Microbiology, College of Veterinary Medicine Seoul National University, Sillim-dong, Gwanak-gu, Seoul 151-742, Republic of Korea. 2KJM Aloe R&D Center, Seongnam-si, Gyeonggi-do, Republic of Korea.
Email: [email protected]

  •  Accepted: 13 May 2011
  •  Published: 16 October 2011


The rapidly emerging rate of antibiotic resistance requires alternative solutions rather than new drugs. Aloe has been used for medical applications and exhibits antimicrobial activity as well as immunomodulation effects. Use of the aloe peel has not been considered, even though it may harbor many useful compounds. In this study, the antimicrobial activity of Aloe vera peel extract in distilled water against Staphylococcus aureusBacillus spp.,Enterococcus spp., Escherichia coliSalmonella typhimurium, Pseudomonas aeruginosa, and Vibrio spp. was ascertained. The number of bacterial colonies were significantly reduced by the application of peel extracts (P<0.05). The antimicrobial activity was especially strong against E. coli and Vibrio spp. (P<0.001). In vivo antimicrobial activity and immunomodulation effects were tested in mice challenged with S. typhimurium DT104. Fecal shedding of S. typhimurium DT104 significantly decreased and intestinal Salmonella specific IgA and IgG titers significantly increased in mice fed with peel extracts. In splenocyte cultures stimulated by concanavalin A, the extract did not affect the production of interleukin IL-2 and interferon-gamma but did promote the production of IL-4 and IL-10. The in vitro and in vivo antimicrobial activities and immunomodulatory properties of A. vera peel extract may be of commercial value.


Key words: Aloe vera, antimicrobial effect, immunomodulatory effect.