Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3597

Full Length Research Paper

Effect of Zingiber officinal (ginger) and Glycyrrhiza uralensis (licorice) on experimental S. mansoni life cycle and investing the composition (metabolites) changes in different tissues

Hanan F. Aly1, Mona M. Mantawy1, Zainb H. Fahamy2 and Maha Zaki Rizk1
1Therapeutic Chemistry Department, National Research Center, El Behooth Street, Dokki, Giza, Egypt. 2Parasitology Department, Theodor Bilharz Research Institute, Imbaba, Giza, Egypt.
Email: [email protected]

  •  Accepted: 31 October 2012
  •  Published: 25 May 2013

Abstract

The present study was undertaken to evaluate the role of both ginger (Zingiber officinal) and licorice (Glycyrrhiza uralensis) on different S. mansoni life cycle; miracidia, cercariae, schistosomula and adult worm in vitro. In addition, this study aimed at separation and quantification of pyruvic, lactic, succnic, fumaric, malic, acetic, propionic and acetoacetic acids in the tissue of each parasite life cycle using ion-suppression reversed -phase high performance liquid chromatography (HPLC) after treatments of the different S. mansoniparasites with the lethal doses of plant extracts. Using such data, we can then evaluate in a broader manner, the physiological processes that cannot permit the parasites to survive under these treatment, and to test the potentiality of these extracts to produce disturbances in these metabolites, as they refer to different metabolic pathways to be used as diagnostic and therapeutic biomarkers.

 

Key words: Zingiber officinalGlycyrrhiza uralensis, metabolites, life cycle.

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