Abstract

The present study was undertaken to evaluate the role of both ginger (Zingiber officinal) and licorice (Glycyrrhiza uralensis) on different S. mansoni life cycle; miracidia, cercariae, schistosomula and adult worm in vitro. In addition, this study aimed at separation and quantification of pyruvic, lactic, succnic, fumaric, malic, acetic, propionic and acetoacetic acids in the tissue of each parasite life cycle using ion-suppression reversed -phase high performance liquid chromatography (HPLC) after treatments of the different S. mansoniparasites with the lethal doses of plant extracts. Using such data, we can then evaluate in a broader manner, the physiological processes that cannot permit the parasites to survive under these treatment, and to test the potentiality of these extracts to produce disturbances in these metabolites, as they refer to different metabolic pathways to be used as diagnostic and therapeutic biomarkers.

Key words: Zingiber officinal, Glycyrrhiza uralensis, metabolites, life cycle.