Full Length Research Paper
Abstract
Herreria salsaparilha is a plant species popularly used for the treatment of syphilis and cutaneous infections. The aim of this work was to evaluate its potential antimicrobial activity against multi-resistant field strains of Escherichia coli, Staphylococcus aureus, their respective ATCC cell lines, and strains of Tricophyton rubrum H6 and T. rubrum mutantDTruMDR2. Additionally, the cytotoxic activity against astrocytoma brain tumor cells (U343), human cervical cancer cells (HeLa) and murine melanoma cells (B16) was investigated. The antimicrobial activity was confirmed against both the S. aureus multi-resistant strain (MIC: 750 µg) and its ATCC strain (MIC: 50 µg). Moreover, the cytotoxic activity was determined for HeLa (IC50: 2 µg) and B16 (IC50: 10 µg) tumor cells.
Key words: Cerrado, salsaparilha, anti-tumoral, Herreriaceae.
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