Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

Herreria salsaparilha Mart.: A potential source of antimicrobial and cytotoxic compounds

Juliana da Silva Coppede, Ana Lucia Fachin, Silvia Helena Taleb Contini, Bianca Waleria Bertoni, Suzelei de Castro Franca and Ana Maria Soares Pereira*
Department of Plant Biotechnology, University of Ribeirão Preto–UNAERP, 14096-900 Ribeirão Preto, São Paulo, Brazil.
Email: [email protected]

  •  Accepted: 13 April 2012
  •  Published: 12 September 2012

Abstract

Herreria salsaparilha is a plant species popularly used for the treatment of syphilis and cutaneous infections. The aim of this work was to evaluate its potential antimicrobial activity against multi-resistant field strains of Escherichia coli, Staphylococcus aureus, their respective ATCC cell lines, and strains of Tricophyton rubrum H6 and T. rubrum mutantDTruMDR2. Additionally, the cytotoxic activity against astrocytoma brain tumor cells (U343), human cervical cancer cells (HeLa) and murine melanoma cells (B16) was investigated. The antimicrobial activity was confirmed against both the S. aureus multi-resistant strain (MIC: 750 µg) and its ATCC strain (MIC: 50 µg). Moreover, the cytotoxic activity was determined for HeLa (IC50: 2 µg) and B16 (IC50: 10 µg) tumor cells.

 

Key words: Cerrado, salsaparilha, anti-tumoral, Herreriaceae.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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