Short Communication
Abstract
The purpose of this study was to evaluate the effect of leaves of Apocynum venetum L.(AV) on the monoamine oxidase (MAO) activity in mice whole brain. After 7 days oral administration, we assayed spectrophotometrically the activity of MAO. The ethanolic extract of leaves of A. venetum (EAV) showed a tendency to inhibit MAO activity in animal brain. However, the aqueous phase of EAV (EAV-4) significantly inhibits the MAO activity. The effect of fluoxetine on activity of MAO was not marked. The aqueous phase of ethanolic extracts of AV significantly inhibited the activity of MAO, which might be the active part of antidepressant effect of AV.
Key words: Apocynum venetum L., monoamine oxidase, monoamines.
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