Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3785

Full Length Research Paper

Pharmacological profile of aqueous extract of Bridelia ferruginea stem bark in the relief of pain and fever

Akuodor G. C.1*, Mbah C. C.2, Anyalewechi N. A.1, Idris-Usman M.1 Iwuanyanwu T. C.1and Osunkwo U. A.1
1Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development (NIPRD), P. M. B. 21 Garki, Abuja, Nigeria. 2Department of Pharmaceutical Technology and Raw Materials Development, National Institute for Pharmaceutical Research and Development (NIPRD), P. M. B. 21 Garki, Abuja, Nigeria.
Email: [email protected]

  •  Accepted: 18 April 2011
  •  Published: 16 October 2011

Abstract

The pharmacological effects of the aqueous stem bark extract of Bridelia ferruginea were studied in rodents. Investigations were carried out on analgesic and antipyretic properties employing different experimental models in mice and rats. The analgesic activity was measured using the acetic acid induced-abdominal constriction and tail immersion tests. The antipyretic effect was assessed using the yeast-induced pyrexia test. It was found that B. ferruginea (25 to 100 mg/kg, i.p) at both doses produced significant analgesic and antipyretic effects. The results clearly indicate that stem bark extract of B. ferruginea possess potential analgesic and antipyretic properties.

 

Key words: Bridelia ferruginea, nociception, pyrexia, medicinal plant.