Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

Inhibitory effect on B16/F10 mouse melanoma cell and HT-29 human colon cancer cell proliferation and cordycepin content of the butanol extract of Paecilomyces militaris

Yi-Qing Li1,2#, Hye-Jin Park1#, Eun-Su Han1 and Dong-Ki Park1*
1Department of Bioscience and Biotechnology, Konkuk University, Seoul, Korea. 2Laboratory for Conservation and Utilization of Bio-Resources and Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan University, Kunming, China.
Email: [email protected]

  •  Accepted: 21 May 2010
  •  Published: 04 April 2011

Abstract

The cultured mycelium of strain Paecilomyces militaris CMG 01 (Pm) was extracted sequentially by hexane, ethyl acetate (EtOAc) and butanol (BuOH). Among them, the BuOH extract exhibited potent anti-proliferative activity on B16/F10 mouse melanoma and HT-29 human colon cancer cells. Active chemical fractions of the Pm BuOH extract led to the isolation of a nucleoside compound, which structure was identified as cordycepin on the basis of 1H, 13C NMR and MS data. The further evaluated on cordycepin showed that cordycepin significantly inhibited B16/F10 and HT-29 cells proliferation and its content in BuOH extract was 68.89 mg/g. our results suggest that the BuOH extract of Pm is a potential source of natural anticancer agents.

 

Key words: Paecilomyces militaris, B16/F10 mouse melanoma cell, HT-29 human colon cancer cell, cordycepin.

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