Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3785

Full Length Research Paper

Antioxidative effect of curcumin (Curcuma longa) on lipid peroxidation and lipofuscinogenesis in submandibular gland of D-galactose-induced aging male mice

P. P. Sarvalkar, M. V. Walvekar and L. P. Bhopale
Department of Zoology, Shivaji University, Kolhapur, 416004 Maharashtra, India.
Email: [email protected]

  •  Accepted: 24 August 2011
  •  Published: 30 September 2011


Extract of turmeric (Curcuma longa) that is, curcumin was examined for antioxidant activity. The study deals with the effects of curcumin on lipid peroxidation and fluorescence product in the control, D-galactose-induced aged, D-galactose aging protected and D-galactose aging cured mice. The level of lipid peroxidation in terms of malondialdehyde and the level of lipofuscin granules in term of fluorescence product increased in submandibular gland of D-galactose-induced aged mice. After curcumin (30 mg/kg body weight) administration the levels of both the parameters reduced significantly. Thus, results suggest that curcumin prevent the formation of malondialdehyde and lipofuscin granules which are indicators of aging.


Key words: Curcumin, antioxidant, lipid peroxidation, lipofuscin granules, submandibular gland.