The mushrooms were screened for their antimicrobial, and cytotoxicity, six strains of bacteria viz. Staphylococcus aureus (ATCC6538), Bacillus subtilis (ATCC6633), Vibrio cholerae(ATCC6643), Escherichia coli (ATCC15224), Klebsiella pneumoniae (MTCC618) andEnterobacter aerogenes (ATCC13048) were utilized as test organisms for determination of antibacterial activity. Maximum antibacterial activity was observed at 30 mg/ml concentration of extracts. Greater inhibitory activity against S. aureus was possessed by methanolic and ethanolic extracts of Calvatia gigantean. The methanolic extract of Morchella esculentaexhibited maximum inhibitory activity against V. cholerae and also the ethanolic extract showed higher bactericidal activity against E. coli. But the selected mushrooms exhibited no significant antifungal activity against Aspergillus fumigatus and Aspergillus niger.
Key words: Mushrooms, medicinal, South Waziristan Agency.
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