Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

Effects of Malaysian medicinal plants on macrophage functions in vitro study

Fouad H. Al- Bayaty1, Mahmood A. Abdulla, Mohamed2, I. Abu Hassan1 and Saba F. Hussein1
1Department of Restorative Dentistry, Faculty of Dentistry, Universiti Teknologi MARA , Level 19, Tower 2, Shah Alam, 40450, Malaysia. 2Department of Molecular Medicine, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia 50603.
Email: [email protected]

  •  Accepted: 13 July 2010
  •  Published: 30 September 2013


The effects of aqueous leaf extract of eight local medicinal plant species on the phagocytic and antibacterial potential of mouse peritoneal macrophages againstStaphylococcus aureus were investigated. The mouse macrophages cultures were incubated with various concentrations (0.2, 0.4, 0.8, 1.6 and 3.2 mg/ml) of plant extracts in different sets of test tubes at 37°C for one hour.  After incubation, their phagocytic and antibacterial effects on S. aureus were determined.  Results have shown that the extracts of Orthosiphon stramineus, and Andrographis paniculatainhibited the phagocytic activity and intracellular killing of S. aureus compared with controls. Activated cells had more phagocytic activity and intracellular killing than normal macrophages. There were no differences in the viability of macrophage cells treated with extracts and those without extracts (control).


Key words: Aqueous plant extracts, murine macrophages, phagocytosis.