Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3702

Short Communication

Lipid profile status of streptozotocin induced diabetic rats treated with ethanolic leaf extract of Solenostemon monostachyus

Dennis Amaechi*
  • Dennis Amaechi*
  • Biochemistry Department, Faculty of Basic Medical Sciences, University of Calabar, Calabar, Cross Rivers State, Nigeria.
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E. O. Udosen
  • E. O. Udosen
  • Biochemistry Department, Faculty of Basic Medical Sciences, University of Calabar, Calabar, Cross Rivers State, Nigeria.
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E. E. Edet
  • E. E. Edet
  • Biochemistry Department, Faculty of Basic Medical Sciences, University of Calabar, Calabar, Cross Rivers State, Nigeria.
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E. E. Asanga
  • E. E. Asanga
  • Biochemistry Department, Faculty of Basic Medical Sciences, University of Calabar, Calabar, Cross Rivers State, Nigeria.
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I. E. Mbakwe
  • I. E. Mbakwe
  • Biochemistry Department, Faculty of Basic Medical Sciences, University of Calabar, Calabar, Cross Rivers State, Nigeria.
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  •  Received: 29 October 2014
  •  Accepted: 19 February 2015
  •  Published: 25 February 2015

Abstract

Lipid profile status of streptozotocin induced diabetic rats treated with ethanolic leaf extract of Solenostemon monostachyus was assessed. A total of 24 rats were used for the experiments and were divided into four groups (that is, Diabetic Control (DC), Normal Control (NC), Insulin Treated (INS) and S. monostachyus (SM) treated groups), with 6 rats each. The extract, 250 mg/kg body weight, was administered twice daily for 21 days. The serum glucose level in mg/dl was 70.00±10.50 for SM treated groups, 256.00±15.00 for DC. There was significant decrease at p>0.05 in blood glucose of rats administered with the extract. The lipid profile values for SM were triacylglycerol (TG, 58.00±2.00), total cholesterol (TC, 35.00±1.00), high density lipoprotein cholesterol (HDL-c, 35.00±1.00), very low density lipoprotein cholesterol (VLDL-c, 16.90±0.30), low density lipoprotein cholesterol (LDL-c, 14.70±0.53) and for DC were TG (155.47±2.76), TC (137.88±5.91), HDL-c (31.94±2.93), VLDL-c (27.54±1.15), LDL-c (95.99±4.72). The result for the lipid profile of SM treated groups showed significant decrease (P>0.05), when compared with DC groups. Based on the results obtained from this study, it may be concluded that the ethanolic leaf extract of SM has hypoglycaemic properties and was able to alleviate elevations in lipid profile and oxidative stress induced by streptozotocin in Wistar albino rats.

 

Key words: Solenostemon monostachyus, hypoglycaemic, oxidative stress.