Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

Eupalitin from Asparagus falcatus (Linn.) has anti-cancer activity and induces activation of caspases 3/7 in human colorectal tumor cells

Raza Murad Ghalib1*, Sayed Hasan Mehdi2, Rokiah Hashim2, Othman Sulaiman2, Fiona How Ni Foong1, B. M. Khadeer Ahamed3, Amin Malik Shah Abdul Majid3 and Faiyaz Ahmed4
1Department of Chemistry, Kulliyaah of Science, IIUM, Kuantan, Malaysia. 2School of Industrial Technology, Universiti Sains Malaysia, Minden–11800, Pulau Pinang, Malaysia. 3Department of Pharmacology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden–11800, Pulau Pinang, Malaysia. 4Indian Institute of Crop Processing Technology, Ministry of Food Processing Industries, Govt of India, Pudukkottai Road, Thanjavur 613 005, Tamil Nadu, India.
Email: [email protected]

  •  Accepted: 13 May 2013
  •  Published: 25 May 2013

Abstract

3,5,4′-Trihydroxy-6,7-dimethoxy-flavone (Eupalitin) has been isolated from the leaves ofAsparagus falcatus (Linn.). Anti-proliferation and apoptosis studies were conducted on eupalitin. Results showed that eupalitin exhibited significant cytotoxicity against human colorectal tumor cells. It is found that eupalitin induces the activation of caspases 3/7, a hallmark of apoptosis. The study suggests that the anti-proliferative property of eupalitin towards the human colorectal tumor cells may be probably due to its capability to induce apoptosis in cells.

 

Key words: 3,5,4′-Trihydroxy-6,7-dimethoxy-flavone, eupalitin, Asparagus falcatus (Linn.), cytotoxicity, colorectal cancer, caspases.

Copyright © 2024 Author(s) retain the copyright of this article.

This article is published under the terms of the Creative Commons Attribution License 4.0

Back to Vol. 7 No. 20
Back to articles
  • Articles on Google by:
SUBSCRIBE TO RSS
SUBMIT MANUSCRIPT
CONFERENCES