Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

Seven alkaloids and their antibacterial activity from Hypecoum erectum L.

Yinfen Su, Shengkun Li, Na Li, Liling Chen, Jiwen Zhang and Junru Wang*
Northwest A & F University, Yangling Shaanxi 712100, China.
Email: [email protected]

  •  Accepted: 08 September 2011
  •  Published: 16 October 2011


From the aerial part of Hypecoum erectum L., seven alkaloids, Protopine (1), Cryptopine (2), Allocryptopine (3), Hypecorinine (4), (-)-N-Methylcanadine (5), Oxohydrastinine (6) and N-Methylcorydaldine (7) were isolated. The structures of the seven compounds were established by 1H-NMR, 13C-NMR, DEPT and ESI-MS analyses. Compounds 2, 5 and 7 were obtained from this plant for the first time. The antibacterial activities were investigated against six bacteria (3 gram-positive and 3 gram-negative) by disc diffusion method followed by the minimal inhibitory concentration (MIC) which was determined using a two fold serial dilution assay for the compound which have inhibitory effect. In vitro antimicrobial activities assay indicated that some compounds showed promising activities. To the best of our knowledge, this is the first report on the antimicrobial properties of these alkaloids from this plant.


Key words: Hypecoum erectum L., alkaloids, antimicrobial activity.