Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

Inhibition of the principal enzymatic and biological effects of the crude venom of Bothrops atrox by plant extracts

Valéria Mourão de Moura1, Luciana A. F. de Sousa1, Ricardo Bezerra de Oliveira1, Ana M. Moura da Silva2, Hipócrates de M. Chalkidis3, Milton Nascimento da Silva4, Sergio Pacheco5 and Rosa H. Veras Mourão1*
1Graduate Program in Natural Resources from Amazon - PGRNA, Laboratory of Experimental Biology and Bioprospecting - LabBBEx, Federal University of Western Pará - UFOPA, 68035-110 Santarém, PA, Brazil. 2Immunopathology laboratory, Instituto Butantan, 05503-900, São Paulo, SP, Brazil. 3Zoological Research Laboratory - LPZ, Integrated College Tapajós - FIT, 68010-200 Santarém, PA, Brazil. 4Graduate Program in Chemistry - PPGQ, Laboratory of Liquid Chromatography - LABCROL, Federal University of Pará - UFPA, 66075-110, Belém, PA, Brazil. 5Federal University of Viçosa - Av. P. H. Rolfs s/n, 36570-000, Viçosa, MG, Brazil.
Email: [email protected]

  •  Accepted: 19 July 2013
  •  Published: 17 August 2013

Abstract

This study analyzes the effectiveness of extracts from five plant species used for treating venomous snakebites in the region of Santarém, in central Brazilian Amazonia. The aqueous extracts of Bellucia dichotoma Cogn., Connarus favosus Planch., Aniba fragrans Ducke,Plathymenia reticulata Benth., and Philodendron megalophyllum Schott were prepared by decoction at 70°C and lyophilized. Inhibition of the enzymatic activity and biological effects of the crude venom of Bothrops atrox was tested by pre-incubating different concentrations (1:1 to 1:30 venom:extract, w/w) for 30 min at 37°C. These results confirm traditional local knowledge on the anti-toxin powers of the native plants of the Amazon basin and the potential of these extracts as toxin inhibitors and as an alternative or complement for the standard treatment of snakebite based on the application of antisera.

 

Key words: Natural inhibitors, Bothrops atrox, Bellucia dichotoma, Connarus favosus, Plathymenia reticulata, Philodendron megalophyllum, Aniba fragrans.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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