Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3843

Full Length Research Paper

Effect of Ephedra foeminea active compounds on cell viability and actin structures in cancer cell lines

Maayan Mendelovich
  • Maayan Mendelovich
  • Institute of Plant Sciences, Agriculture Research Organization, Volcani Center, Rishon LeZion 75822, Israel.
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Monick Shoshan
  • Monick Shoshan
  • Institute of Plant Sciences, Agriculture Research Organization, Volcani Center, Rishon LeZion 75822, Israel.
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Marcelo Fridlender
  • Marcelo Fridlender
  • Institute of Plant Sciences, Agriculture Research Organization, Volcani Center, Rishon LeZion 75822, Israel.
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Moran Mazuz
  • Moran Mazuz
  • Institute of Plant Sciences, Agriculture Research Organization, Volcani Center, Rishon LeZion 75822, Israel.
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Dvora Namder
  • Dvora Namder
  • Institute of Plant Sciences, Agriculture Research Organization, Volcani Center, Rishon LeZion 75822, Israel.
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Rameshprabu Nallathambi
  • Rameshprabu Nallathambi
  • Institute of Plant Sciences, Agriculture Research Organization, Volcani Center, Rishon LeZion 75822, Israel.
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Gopinath Selvaraj
  • Gopinath Selvaraj
  • Institute of Plant Sciences, Agriculture Research Organization, Volcani Center, Rishon LeZion 75822, Israel.
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Puja Kumari
  • Puja Kumari
  • Institute of Plant Sciences, Agriculture Research Organization, Volcani Center, Rishon LeZion 75822, Israel.
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Aurel Ion
  • Aurel Ion
  • Institute of Plant Sciences, Agriculture Research Organization, Volcani Center, Rishon LeZion 75822, Israel.
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Smadar Wininger
  • Smadar Wininger
  • Institute of Plant Sciences, Agriculture Research Organization, Volcani Center, Rishon LeZion 75822, Israel.
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Ahmad Nasser
  • Ahmad Nasser
  • The Interinstitutional Analytical Instrumentation Unit (IU), Agriculture Research Organization, Volcani Center, Rishon LeZion 75822, Israel.
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Mohamed Samara
  • Mohamed Samara
  • The Interinstitutional Analytical Instrumentation Unit (IU), Agriculture Research Organization, Volcani Center, Rishon LeZion 75822, Israel.
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Yaacov Sharvit
  • Yaacov Sharvit
  • Institute for Apitherapy, Department of Medicinal Plants and Natural Compounds, Tu Beav 181, Shiloh, 4483000, Israel.
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Yoram Kapulnik
  • Yoram Kapulnik
  • Institute of Plant Sciences, Agriculture Research Organization, Volcani Center, Rishon LeZion 75822, Israel.
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Native Dudai
  • Native Dudai
  • The Unit of Aromatic and Medicinal Plants, Newe Yaar Research Center, ARO, Ramat Yishai 30095, Israel.
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Hinanit Koltai
  • Hinanit Koltai
  • Institute of Plant Sciences, Agriculture Research Organization, Volcani Center, Rishon LeZion 75822, Israel.
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  •  Received: 19 August 2017
  •  Accepted: 24 October 2017
  •  Published: 17 November 2017

References

Abourashed EA, El-Alfy AT, Khan IA, Walker L (2003). Ephedra in perspective – a current review. Phytother. Res. 17:703-712.
Crossref
 

Ali-Shtayeh MS, Jamous RM, Salameh NM, Jamous RM, Hamadeh AM (2016). Complementary and alternative medicine use among cancer patients in Palestine with special reference to safety-related concerns. J. Ethnopharmacol. 187:104-122.
Crossref

  
 

Arocho A, Chen B, Ladanyi M, Pan Q (2006). Validation of the 2-ΔΔCt calculation as an alternate method of data analysis for quantitative PCR of BCR-ABL P210 transcripts. Diagn. Mol. Pathol. 15:56-61.
Crossref

  
 

Astrup A, Breum L, Toubro S (1995). Pharmacological and clinical studies of ephedrine and other thermogenic agonists. Obes. Res. 3:537-540.
Crossref

  
 

Ben-Arye E, Mahajna J, Aly R, Ali-Shtayeh MS, Bentur Y, Lev E, Deng G, Samuels N (2016). Exploring an herbal "wonder cure" for cancer: a multidisciplinary approach. J. Cancer Res. Clin. Oncol. 142(7):1499-1508.
Crossref

  
 

Foda HD, Zucker S (2001). Matrix metalloproteinases in cancer invasion, metastasis and angiogenesis. Drug Discov. Today 6:478-482.
Crossref

  
 

Gurley BJ, Wang P, Gardner SF (1998). Ephedrine‐type alkaloid content of nutritional supplements containing Ephedra sinica (ma‐huang) as determined by high performance liquid chromatography. J. Pharm. Sci. 87:1547-1553.
Crossref

  
 

Halket JM, Waterman D, Przyborowska AM, Patel RK, Fraser PD, Bramley PM (2004). Chemical derivatization and mass spectral libraries in metabolic profiling by GC/MS and LC/MS/MS. J. Exp. Bot. 56:219-243.
Crossref

  
 

Ickert-Bond SM, Rydin C, Renner SS (2009). A fossil‐calibrated relaxed clock for Ephedra indicates an Oligocene age for the divergence of Asian and New World clades and Miocene dispersal into South America. J. Syst. Evol. 47:444-456.
Crossref

  
 

Kamath K, Smiyun G, Wilson L, Jordan MA (2014). Mechanisms of inhibition of endothelial cell migration by taxanes. Cytoskeleton (Hoboken) 71:46-60.
Crossref

  
 

Kobayashi S, Endou M, Sakuraya F, Matsuda N, Zhang XH, Azuma M, Echigo N, Kemmotsu O, Hattori Y, Gando S (2003). The sympathomimetic actions of l-ephedrine and d-pseudoephedrine: direct receptor activation or norepinephrine release? Anesth. Analg. 97:1239-1245.
Crossref

  
 

Krizevski R, Bar E, Shalit OR, Levy A, Hagel JM, Kilpatrick K, Marsolais F, Facchini PJ, Ben-Shabat S, Sitrit Y, Lewinsohn E (2012). Benzaldehyde is a precursor of phenylpropylamino alkaloids as revealed by targeted metabolic profiling and comparative biochemical analyses in Ephedra spp. Phytochemistry 81:71-79.
Crossref

  
 

Mayzlish-Gati E, Laufer D, Grivas CF, Shaknof J, Sananes A, Bier A, Ben-Harosh S, Belausov E, Johnson MD, Artuso E, Levi O, Genin O, Prandi C, Khalaila I, Pines M, Yarden RI, Kapulnik Y, Koltai H (2015). Strigolactone analogs act as new anti-cancer agents in inhibition of breast cancer in xenograft model. Cancer Biol. Ther. 16:1682-1688.
Crossref

  
 

Mehner C, Hockla A, Miller E, Ran S, Radisky DC, Radisky ES (2014). Tumor cell-produced matrix metalloproteinase 9 (MMP-9) drives malignant progression and metastasis of basal-like triple negative breast cancer. Oncotarget 5:2736-2749.
Crossref

  
 

Nagappan R (2012). Evaluation of aqueous and ethanol extract of bioactive medicinal plant, Cassia didymobotrya (Fresenius) Irwin & Barneby against immature stages of filarial vector, Culex quinquefasciatus Say (Diptera: Culicidae). Asian Pac. J. Trop. Biomed. 2(9):707-711.
Crossref

  
 

Normile D (2003). The new face of traditional Chinese medicine. Science 299:188-190.
Crossref

  
 

Schiff PB, Fant J, Horwitz SB (1979). Promotion of microtubule assembly in vitro by Taxol. Nature 277:665-667.
Crossref

  
 

Snyder LR, Kirkland JJ, Glajch JL (2012). Practical HPLC method development. John Wiley & Sons.

  
 

Yamaguchi H (2012). Pathological roles of invadopodia in cancer invasion and metastasis. Eur. J. Cell Biol. 91:902-907.
Crossref

  
 

Yamaguchi H, Condeelis J (2007). Regulation of the actin cytoskeleton in cancer cell migration and invasion. Biochim. Biophys. Acta 1773:642-652.
Crossref

  
 

Yeung AY (1980). Encyclopedia of common natural ingredients. John Willey & Sons, New York, USA. pp. 166-167.

  
 

Yvon AMC, Wadsworth P, Jordan MA (1999). Taxol suppresses dynamics of individual microtubules in living human tumor cells. Mol. Biol. Cell. 10:947-959.
Crossref

  
 

Zhao Y, Hao X, Lu W, Cai J, Yu H, Sevénet T, Guéritte F (2002). Syntheses of two cytotoxic sinapyl alcohol derivatives and isolation of four new related compounds from Ligularia nelumbifolia. J. Nat. Prod. 65:902-908.
Crossref

  
 

Zhao Y, Zhongjian J, Yang L (1994). Sinapyl alcohol derivatives and other constituents from Ligularia Nelumbifolia. Phytochemistry 37:1149-1152.
Crossref

  
 

Zou HB, Dong SY, Zhou CX, Hu LH, Wu YH, Li HB, Gong JX, Sun LL, Wu XM, Bai H, Fan BT, Hao XJ, Stöckigt J, Zhao Y (2006). Design, synthesis, and SAR analysis of cytotoxic sinapyl alcohol derivatives. Bioorg. Med. Chem. 14:2060-2071.
Crossref

  

 

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