Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3749

Full Length Research Paper

Toxicological evaluation of Zanthoxylum zanthoxyloides (Lam) Zepernick & Timler root bark used as biopesticide and medicine

Mohammed Gbate
  • Mohammed Gbate
  • Biological Science Department, Federal Polytechnic, Bida, Niger State, Nigeria
  • Google Scholar
Olufemi Michael Ashamo
  • Olufemi Michael Ashamo
  • Department of Biology, Federal University of Technology, Akure, Ondo State, Nigeria.
  • Google Scholar
Akinwande Lawrence Kayode
  • Akinwande Lawrence Kayode
  • Department of Biology, Federal University of Technology, Akure, Ondo State, Nigeria.
  • Google Scholar

  •  Received: 22 December 2020
  •  Accepted: 15 February 2021
  •  Published: 28 February 2021


Adebiyi OE, Obatan MO (2013). Phytochemical and acute toxicity of ethanolic extract of Enantia chlorantha (Oliv) stem bark in albino rats. Interdisciplinary Toxicology 6(3):145-151.


Adekunle AS, Kamdem JP, Rocha JBT (2012). Antioxidant Activity and HPLC Analysis of Zanthozylum zanthoxyloides. Report and Opinion 4(3):6-13



Adeyemo-Salami OA, Makinde JM (2013). Acute and subacute toxicity studies of the methanol extract of the leaves of Paullinia pinnata (Linn.) in Wistar albino mice and rats. African Journal of Medicine and Medical Sciences 42:81-90.


Alelign T, Chalchisa D, Fekadu N, Solomon D, Sisay T, Debella F, Petros B (2020). Evaluation of acute and sub-acute toxicity of selected traditional antiurolithiatic medicinal plant extracts in Wistar albino rats. Toxicology Reports 7:1356-1365 


Anokbonggo W, Odoi-Adome R, Oluju P (1990). Traditional methods in management of diarrhoeal diseases in Uganda. Bulletin of the World Health Organization 68:359.


Barnabas BB, Mann A, Ogunrinola TS, Anyanwu PE (2011). Screening for Anthelminthic activities from extracts of Zanthoxylum Zanthoxyloides, Neocarya Macrophylla and Celosia Laxa against Ascaris infection in Rabbits. International Journal of Applied Research in Natural Products 3(4):1-4.


Buxton T, Takahashi S, Takakura M, Niwata I, Owusu EO, Kim C (2017). Insecticidal activities of pellitorine isolated from Zanthoxylum zanthoxyloides roots against Sitophilus oryzae L. (Coleoptera: Curculionidae). Journal of Entomology and Zoology Studies 5(3):163-168.


Chaaib F, Queiroz EF, Ndjoko K, Diallo D, Hostettmann K (2003). Antifungal and antioxidant compounds from the root bark of Fagara zanthoxyloides. Planta Medica 69:316-320. 


Cheng MJ, Lee KH, Tsai IL, Chen IS (2005). Two new sesquiterpenoids and anti-HIV principles from the root bark of Zanthoxylum ailanthoides. Bioorganic and Medicinal Chemistry 13:5915-5920. 


de Abreu W, Weber AD, Giacomelli SR, Simionatto E, Dalcol II, Dessoy ECM, Morel AF (2003). Composition and antibacterial activity of the essential oils from Zanthoxylum rhoifolium. Planta Medica 69:773-775. 


de Moura NF, Ribeiro HB, Machado EC, Ethur EM, Zanatta N, Morel AF (1997). Benzophenanthridine alkaloids from Zanthoxylum rhoifolium. Phytochemistry 46:1443-1446.


Dongmo PMJ, Ngoune LT, Kenfack SM, Dongmo BN, Zollo PHA, Menut C (2009). Inhibitory Effect of Essential Oils of Some Cameroonian Zanthoxylum (Rutaceae) Against Fusarium Solani. European Journal of Scientific Research 34(1):34-45


Ferreira ME, Nakayama H, de Arias AR, Schinini A, de Bilbao NV, Serna E, Lagoutte D, Soriano-Agatón F, Poupon E, Hocquemiller R (2007). Effects of canthin-6-one alkaloids from Zanthoxylum chiloperone on Trypanosoma cruzi-infected mice. Journal of Ethnopharmacology 109:258-263. 


Gbate M, Alhassan I (2004). Laboratory assessment of termiticidal effect of some plants. Nigerian Journal of Arts, Science and Technology 2:2-8.


Gbate M, Fasoranti JO (2008). Comparative assessment of Zanthoxylum zanthoxyloides (Lam) Zepernick&Timler, Piper guineenseSchum&Thonn, HyptissuavolensPoit and Pirimphos methyl (synthetic insecticide) for arresting Callosobruchus maculates F. infestation in Vigna unguiculata (L) Walp. Nigerian Journal of Arts, Science and Technology 4(2):215-225.


Groppo M, Kallunki JA, Pirani JR, Antonelli A (2012). Chilean Pitavia more closely related to Oceania and Old World Rutaceae than to Neotropical groups: evidence from two cpDNA non-coding regions, with a new sub familial classification of the family. Phytokeys 19:9-29.


Ileke KD, Ogungbite OC (2014). Entomocidal Activity of powders and extracts of four medicinal plants against Sitophilus oryzae (L), Oryzaephilusmercator (Faur) and Ryzopertha dominica (Fabr.) Jordan Journal of Biological Sciences 7(1):57-62


Ileke KD, Odeyemi OO, Ashamo MO, Oboh G (2014). Toxicological and histopathological effects of cheesewood, Alstonia booneide Wild, stem bark powder used as cowpea protectant against cowpea bruchid, Callosobruchus maculatus (Fab.) [Coleoptera: Chrysomelidae] on albino rats. Ife Journal of Science 16:23-33.


Jullian V, Bourdy G, Georges S, Maurel S, Sauvain M (2006).Validation of use of a traditional antimalarial remedy from French Guiana, Zanthoxylum rhoifolium Lam. Journal of Ethnopharmacology 106(3):348-352.


Larsen BHV, Soelberg J, Jäger AK (2015). COX-1 inhibitory effect of medicinal plants of Ghana. South African Journal of Botany 99:129-131.


Li G, Xin F, Sheng W (2005). Effects of Cu/Zn Superoxide dismutase on strain - injury induced oxidative damage to skeletal muscle in rats. Physiological Research 54(2):193-199.


Mann A, Gbate M, Nda, AU (2003). Medicinal and Economic plants of Nupeland. Jube -Evans Books and Publications, Bida, Nigeria. p. 271


McGill MR (2016). The past and present of serum aminotransferases and the future of liver injury biomarkers. EXCLI Journal 15:817-828.


Nissanka AP, Karunaratne V, Bandara BR, Kumar V, Nakanishi T, Nishi M, Inada A, Tillekeratne L, Wijesundara D, Gunatilaka AL (2001). Antimicrobial alkaloids from Zanthoxylum tetraspermum and caudatum. Phytochemistry 56:857-861. 


Nwosu LC, Adedire CO, Ogunwolu EO, Ashamo MO (2017). Toxicological and histopathological effects of Dennettia tripetala seed used as grain protectant, food, and medicine. Food Quality and Safety 1(3):211-219. 


Odeyemi OO, Masika P, Afolayan AJ (2008). A review of the use of phytochemicals for insect pest control. African Plant Protection 14:1-7.


Ogunwolu EO, Igoli JO, Longe NN (1998). Reduction in reproductive fitness of Callosobruchus maculates (F) exposed to Powdered Zanthoxylum zanthoxyloides (Lam) Western. Journal of Herbs, Spices and Medicinal Plants 6(1):11-27.


Osabutey AF, Eziah V, Owusu EO (2015). Larvicidal effect of methanol extracts of Zanthoxylum zanthoxyloides (lam) against the diamond back moth, Plutella xylostella (L) (Lepidoptera: Plutellidae) on Cabbage. Journal of the Ghana Science Association 16(2):21-35


Osabutey AF, Vincent EV, Buxton T, Owusu EO (2018). Evaluating the insecticidal potential of aqueous plant extracts from Zanthoxylum zanthoxyloides and Anacardium occidentale against insect pest complexes of cabbage in an open field experiment. International Journal of Agricultural Science Research 7(3):018-027.


Ouattara B, Angenot L, Guissou P, Fondu P, Dubois J, Frédérich M, Jansen O, van Heugen J C, Wauters JN, Tits M (2004). LC/MS/NMR analysis of isomeric divanilloylquinic acids from the root bark of Fagara zanthoxyloides Lam. Phytochemistry 65:1145-1151. 


Queiroz EF, Hay AE, Chaaib F, van Diemen D, Diallo D, Hostettmann K (2006). New and bioactive aromatic compounds from Zanthoxylum zanthoxyloides. Planta Medica 72:746-750. 


Sathya MK, Kokilavani R, Anantateepa KS (2012). Acute and subacute toxicity studies of ethanolic extract of Acalypha indica Linn in male Wistar albino rats. Asian Journal of Pharmaceutical and Clinical Research 5:97-100.


Udo I (2011). Potentials of Zanthoxylum zanthoxyloides (LAM.) for the control of stored product insect pests. Journal of Stored Products and Postharvest Research 2:40-44.


Ujowundu CO, Igwe KO, Agha NC, Okechukwu RI (2014) Toxicological studies in albino rats maintained on fish smoked with firewood and waste tyre materials. Journal of Environmental and Analytical Toxicology 4:258. 


Ulrichova J, Walterova D, Preininger V, Slavik J, Lenfeld J, Cushman M (1983). Inhibition of acetylcholinesterase activity by some isoquinoline alkaloids. Planta Medica 48:111-115 


Yakubu MT, Akanji MA, Oladiji AT (2007). Haematological evaluation in male albino rats following chronic administration of aqueous extract of Fadogia agrestis stem. Pharmacology Magazine 3:34-38.


Zahoui S, Zirihi N, Soro Y, Traore F (2010). Hypotensive effect of a watery extract of Zanthoxylum zanthoxyloides (Lam.) Waterman (Rutacea). Phytotherapie 8(6):359-369.


Zhang W, Zhang Z, Chen Z, Liang J, Geng Z, Guo S, Du S, Deng Z (2017). Chemical composition of essential oils from six Zanthoxylum species and their repellent activities against two stored-product insects. Journal of Chemistry 1-7