Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3605

Full Length Research Paper

Exploring the anticoagulant and antiplatelet effect of the extracts of the red marine alga Acanthophora spicifera

Vivian Rodrigues de Souza
  • Vivian Rodrigues de Souza
  • Institute of Biology, Department of Molecular and Cellular Biology, Federal Fluminense University, Niterói, RJ, 24020-141, Brazil.
  • Google Scholar
Laura de Andrade Moura
  • Laura de Andrade Moura
  • Institute of Biology, Department of Molecular and Cellular Biology, Federal Fluminense University, Niterói, RJ, 24020-141, Brazil.
  • Google Scholar
Ana Claudia Rodrigues da Silva
  • Ana Claudia Rodrigues da Silva
  • Institute of Biology, Department of Molecular and Cellular Biology, Federal Fluminense University, Niterói, RJ, 24020-141, Brazil.
  • Google Scholar
Kelly Ketely Granja Pereira
  • Kelly Ketely Granja Pereira
  • Institute of Biology, Department of Molecular and Cellular Biology, Federal Fluminense University, Niterói, RJ, 24020-141, Brazil.
  • Google Scholar
Caio Cesar Richter Nogueira
  • Caio Cesar Richter Nogueira
  • Institute of Biology, Departament of Marine Biology, Federal Fluminense University, Niterói, RJ, 24020-141, Brazil.
  • Google Scholar
Diana Negrao Cavalcanti
  • Diana Negrao Cavalcanti
  • Institute of Biology, Departament of Marine Biology, Federal Fluminense University, Niterói, RJ, 24020-141, Brazil.
  • Google Scholar
Valeria Laneuville Teixeira
  • Valeria Laneuville Teixeira
  • Institute of Biology, Departament of Marine Biology, Federal Fluminense University, Niterói, RJ, 24020-141, Brazil.
  • Google Scholar
André Lopes Fuly
  • André Lopes Fuly
  • Institute of Biology, Department of Molecular and Cellular Biology, Federal Fluminense University, Niterói, RJ, 24020-141, Brazil.
  • Google Scholar


  •  Received: 01 December 2018
  •  Accepted: 21 December 2018
  •  Published: 25 January 2019

References

Agnelli G (2005). Current issues in anticoagulation. Pathophysiology of Haemostasis and Thrombosis 34(Suppl. 1):2-9.
Crossref

 

Aihara MS, Yamamoto HY (1968). Occurrence of antheraxanthin in two rhodophyceae Acanthophora spicifera and Gracilaria lichenoides. Phytochemistry 7:497-499.
Crossref

 

Alwan A, Maclean DR, Riley LM, d'Espaignet ET, Mathers CD, Stevens GA, Bettcher D (2010). Monitoring and surveillance of chronic non-communicable diseases: progress and capacity in high-burden countries. The Lancet 376:1861–1868.
Crossref

 

Ávila E, Méndez-Trejo MC, Riosmena-Rodríguez R, López-Vivas JM, Sentíes A (2012). Epibiotic traits of the invasive red seaweed Acanthophora spicifera in La Paz Bay, South Baja California (Eastern Pacific). Marine Ecology 33:470–480.
Crossref

 

Bauer M, Lautenschlaeger C, Kempe K, Tauhardt L, Schubert, US, Fischer D (2012). Poly(2-ethyl-2-oxazoline) as alternative for the stealth polymer poly(ethylene glycol): comparison of in vitro cytotoxicity and hemocompatibility. Macromolecular Bioscience 12:986–998.
Crossref

 

Choi JT, Shin KA, Kim YK (2013). Prevalence of aspirin resistance and clinical characteristics in patients with cerebral infarction. Journal Experimental Biomedicine Science 19:233–238.

 

Cirne-Santos CC, de Souza Barros C, Nogueira CCR, Amorim LC, Campos RM, Ratcliffe NA, Teixeira VL, Ferreira DF, Paixão ICN (2018). Antiviral effect of the seaweed Osmundaria obtusiloba against the Zika virus. Journal of Medicinal Plants Research 12:387–395. Provide a valid link.
Crossref

 

Clemetson KJ (2012). Platelets and Primary Haemostasis. Thrombosis Research 129:220–224.
Crossref

 

Collins KG, Fitzgerald GF, Stanton C, Ross RP (2016). Looking beyond the terrestrial: the potential of seaweed derived bioactives to treat non-communicable diseases. Marine Drugs 14:60–91.
Crossref

 

Coughlin SR (2000). Thrombin signalling and protease-activated receptors. Nature 14:258–264.
Crossref

 

Crawley JT, Zanardelli S, Chion CK, Lane DA (2007). The central role of thrombin in hemostasis. Journal of Thrombosis Haemostasis 5:95–101.
Crossref

 

Dayong SHI, Shuju GUO, Xiao F (2011). A new ketosteroid from red alga Acanthophora spicifera. Chinese Journal of Oceanology Limnology 29:674–678.
Crossref

 

de Andrade Moura L, Marqui AC, Domingos TF, Ortiz-Ramirez F, Cavalcanti DN, Teixeira VL, Fuly AL (2014). Antiplatelet and anticoagulant effects of diterpenes isolated from the marine alga, Dictyota menstrualis. Marine Drugs 30:2471-2478.
Crossref

 

de Andrade Moura L, Ortiz-Ramirez F, Cavalcanti DN, Ribeiro SM, Muricy G, Teixeira VL, Fuly AL (2011). Evaluation of marine brown algae and sponges from Brazil as anticoagulant and antiplatelet products. Marine Drugs 9:1346-1358.
Crossref

 

Della-Valle P, Pavani G, D'Angelo A, Crawley JT, Zanardelli S, Chion CK, Lane DA (2007). The protein C pathway and sepsis. The central role of thrombin in hemostasis. Journal of Thrombosis Haemostasis 5:95–101. Provide a valid link.
Crossref

 

DeWald TA, Becker RC (2014). The pharmacology of novel oral anticoagulants. Journal of Thrombosis Thrombolysis 37:217–233.
Crossref

 

Duarte ME, Cauduro JP, Noseda DG, Noseda MD, Gonçalves AG, Pujol CA, Damonte EB, Cerezo AS (2004). The structure of the agaran sulfate from Acanthophora spicifera (Rhodomelaceae, Ceramiales) and its antiviral activity. Relation between structure and antiviral activity in agarans. Carbohydrate Research 22:335–347.
Crossref

 

Duraikannu K, Shameem RK, Anithajothi R, Umagowsalya G, Ramakritinan CM (2014). In-vivo anticancer activity of red algae (Gelidiela acerosa and Acanthophora spicifera). International Journal Pharmaceutical Sciences and Research 35:3347–3352.

 

Flora G, Rani MS (2013). GC-MS analysis of Acanthophora spicifera. International Journal Pharma and Bio Sciences 4:649–653.

 

Fuly AL, Machado OL, Alves EW, Carlini CR (1997). Mechanism of inhibitory action on platelet activation of a phospholipase A2 isolated from Lachesis muta (Bushmaster) snake venom. Thrombosis and Haemostasis 78:1372–1380.
Crossref

 

Furie B, Furie BC (2008). Mechanisms of thrombus formation. The New England Journal of Medicine 359(9):938-949
Crossref

 

Ganesan P, Kumar CS, Bhaskar N (2008). Antioxidant properties of methanol extract and its solvent fractions obtained from selected Indian red seaweeds. Bioresearch Technology 99(8):2717–2723.
Crossref

 

Huntington JA (2014). Natural inhibitors of thrombin. Thrombosis and Haemostasis 112(04):583-589.
Crossref

 

Kijjoa A, Sawangwong P (2004). Drugs and Cosmetics from the Sea. Marine Drugs 2(2):73-82.
Crossref

 

Kilar JA, McLachlan J (1986). Ecological studies of the alga, Acanthophora spicifera (Vahl) Bøerg. (Ceramiales: Rhodophyta): Vegetative fragmentation. Journal of Experimental Marine Biololgy and Ecology 104(1-3):1-21.
Crossref

 

Kumari P, Reddy R, Jha B (2014). Quantification of Selected Endogenous Hydroxy-oxylipins from Tropical Marine Macroalgae. Marine Biotechnology 16:74-87.
Crossref

 

Kwak JY (2014). Fucoidan as a marine anticancer agent in preclinical development. Marine Drugs 12(2):851-870.
Crossref

 

Lorigooini Z, Ayatollahi SA, Amidi S, Kobarfard F (2015). Evaluation of anti-platelet aggregation Effect of some allium species. Iranian Journal of Pharmaceutical Research 14(4):1225.

 

Mourão PA (2015). Perspective on the use of sulfated polysaccharides from marine organisms as a source of new antithrombotic drugs. Marine Drugs 13(5):2770-2784.
Crossref

 

Newman DJ, Cragg GM (2016). Natural products as sources of new drugs from 1981 to 2014. Journal of Natural Products 79(3):629-661.
Crossref

 

Nogueira CCR, Paixão ICN, Cirne-Santos CC, Stephens PRS, Villaça R C, Pereira HS, Teixeira VL (2016). Anti-HIV-1 activity in human primary cells and Anti-HIV1 RT inhibitory activity of extracts from the red seaweed Acanthophora spicifera. Journal of Medicinal Plants Research 10:621–625.
Crossref

 

Nutescu EA, Burnett A, Fanikos J, Spinler, S, Wittkowsky A (2016). Pharmacology of anticoagulants used in the treatment of venous thromboembolism. Journal of Thrombosis Thrombolysis 42(2): 296-311.
Crossref

 

Nutescu EA, Shapiro NL, Chevalier A, Amin AN (2005). A pharmacological overview of current and emerging anticoagulants. Cleveland Clinic Journal of Medicine 72:2–6.
Crossref

 

Pimentel SM, Bojo ZP, Roberto AV, Lazaro JE, Mangalindan GC, Florentino LM, Lim-Navarro P, Tasdemir D, Ireland CM (2003). Concepcion GP. Platelet aggregation inhibitors from Philippine marine invertebrate samples screened in a new microplate assay. Marine Biotechnology (NY) 5(4):395-400.
Crossref

 

Polat S, Ozogul Y (2008). Biochemical composition of some red and brown macro algae from the Northeastern Mediterranean Sea. International Journal of Food Science Nutrition 59(7-8):566-572.
Crossref

 

Qiu Y, Ciciliano J, Myers DR, Tran R, Lam WA (2015). Platelets and physics: How platelets "feel" and respond to their mechanical microenvironment. Blood Review 29(6):377-386.
Crossref

 

Roth GA, Huffman MD, Moran AE, Feigin V, Mensah GA, Naghavi M, Murray CJ (2015). Global and regional patterns in cardiovascular mortality from 1990 to 2013. Circulation 132(17):1667-1678.
Crossref

 

Ruggeri ZM (2002). Platelets in atherothrombosis. Nature Medicine 8(11):1227
Crossref

 

Wang SC, Bligh SWA, Shi SS, Wang ZT, Hu ZB, Crowder J, Branford-White C, Vella C (2007). Structural features and anti-HIV- 1 activity of novel polysaccharides from red algae Grateloupia longifolia and Grateloupia filicina. International Journal of Biological Macromolecules 41(4):369-375.
Crossref

 

Yoon EK, Ku SK, Lee W, Kwak S, Kang H, Jung B, Bae JS (2015). Antitcoagulant and antiplatelet activities of scolymoside. BMB Reports 48(10):577.
Crossref

 

Zhao J, Yang D, Zheng D (2017). Coagulation is more affected by quick than slow bleeding in patients with massive blood loss. Blood Coagulation Fibrinolysis 28(2):121-125.