Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

Acute oral toxicity study of Mystroxylon aethiopicum root bark aqueous extract in albino mice

Mhuji Kilonzo
  • Mhuji Kilonzo
  • School of Life Sciences and Bio-Engineering, Nelson Mandela African Institution of Science and Technology, P. O. Box 447, Arusha-Tanzania.
  • Google Scholar
Patrick A. Ndakidemi
  • Patrick A. Ndakidemi
  • School of Life Sciences and Bio-Engineering, Nelson Mandela African Institution of Science and Technology, P. O. Box 447, Arusha-Tanzania.
  • Google Scholar
Musa Chacha*
  • Musa Chacha*
  • School of Life Sciences and Bio-Engineering, Nelson Mandela African Institution of Science and Technology, P. O. Box 447, Arusha-Tanzania.
  • Google Scholar


  •  Received: 31 August 2016
  •  Accepted: 19 September 2016
  •  Published: 03 October 2016

References

Ajagbonna OP, Onifade KI, Suleiman U (1999). Hematological and biochemical changes in rats given extract of Calotropis procera. Sok. J. Vet. Sci. 1(1):36-42.

 

Boera HJ, Koola A, Broberg A, William R, Mziray WR, Hedberg I, Levenfors JJ (2005). Anti-fungal and anti-bacterial activity of some herbal remedies from Tanzania. J. Ethnopharmacol. 96:461-469.
Crossref

 

Burkil HM (2004). The useful plants of west tropical Africa. Publisher Royal Botanic Gardens; Kew. pp. 25-28.

 

Burrows JE, Willis CK (2005). Plants of the Nyika Plateau: an account of the Nyika National Parks of Malawi and Zambia. Southern African Botanical Diversity Network Report No. 31. SABONET, Pretoria.

 

Curtis BA, Mannheimer CA (2005). Tree Atlas of Namibia National Botanic Research Institute. Windhoek. pp. 406-407.

 

Dybing E, Doe J, Groten J, Kleiner JO, Brien J (2002). Hazard characterization of chemicals in food and diet: dose response, mechanism and extrapolation issues. J. Food Chem. Toxicol. 40(2):237-282.
Crossref

 

Ndukui JG, Mugisha K, Owiny D, Waako P (2014). Effects of crude aqueous leaf extracts of Citropsis articulata and Mystroxylon aethiopicum on sex hormone levels in male albino rats. Int. J. Pharm. Sci. Inven. 3(1):5-17.

 

Gautam MK, Goel RK (2014). Toxicological study of Ocimum sanctum Linn Leaves: Hematological, biochemical and histopathological studies. J. Toxicol. 9:312-342.

 

Gurib-Fakim A (2006). Medicinal plants: traditions of yesterday and drugs of tomorrow. Mol. Aspect. Med. 27(1):1-93.
Crossref

 

Iwu MM (2014). Handbook of African medicinal plants. Second edition: CRC Press, Taylor & Francis Group. pp. 28-29.
Crossref

 

Jothy LS, Zakaria Z, Chen Y, Ling Lau Y, Yoga Latha L, Sasidharan S (2011). Acute oral toxicity of methanolic seed extract of Cassia fistula in mice. Mol. 16(6):5268-5282.
Crossref

 

Kokwaro JO (1993). Medicinal plants of East Africa. Second edition: Published and printed by Kenya literature bureau, Nairobi Kenya. pp. 176-177.

 

Newman DJ, Cragg GM, Snader KM (2000). The influence of natural products upon drug discovery. Nat. Prod. Rep. 17(3):215-234.
Crossref

 

Olowa LF, Nu-eza OM (2013). Brine shrimp lethality assay of the ethanolic extracts of three selected species of medicinal plants from Iligan City, Philippines. Int. Res. J. Biol. Sci. 2(11):74-77.

 

Olson HG, Betton D, Robinson D, Thomas K, Monro A, Kolaja G, Lilly P, Sanders J, Sipes G, Bracken W, Dorato M, Van Deun K, Smith P, Berger B, Heller A (2000). Concordance of the toxicity of pharmaceuticals in humans and in animals. Regul. Toxicol. Pharm. 32(1):56-67.
Crossref

 

Organization for Economic Cooperation and Development (OECD) (2001). Guidelines for testing of chemicals. Health effects - Test No. 425: Acute oral toxicity: Up-and-Down procedure. 

View

 

Phani K, Kumar AR (2014). Toxicity studies of combined extracts of Vitex leucoxylon, Vitex negundo and Vitex trifolia. J. Chem. Pharm Sci. 7(1):54-58.

 

Pope GV (1995). Flora Zambesiaca: Mozambique, Malawi, Zambia, Zimbabwe, Botswana. Flora Zambesiaca Management Committee.

 

Raza M, Al-Shabanah OA, El-Hadiyah TM, Al-Majed AA (2002). Effect of prolonged vigabatrin treatment on hematological and biochemical parameters in plasma, liver and kidney of Swiss albino mice. J. Sci. Pharm. 70(2):135-145.

 

Reddy RR, Lokanatha O, Ratnam K, Reddy CS, Raju IN, Reddy CD (2013). Acute and sub-acute toxicity of Moringa oleifera stem bark extract in Swiss albino mice. Int. J. Sci. Biotech. Pharm. Res. 2(4):74-82.

 

Schmidt E, Lotter M, McCleland W (2002). Trees and shrubs of Mpumalanga and Kruger national park. Jacana Media. pp. 356-359.

 

Shah R, Parmar S, Bhatt P, Chandra S (2011). Evaluation of hepatoprotective activity of ethyl acetate fraction of Tephrosia purpurea. Pharmacology 3:188-194.

 

StatSoft Inc. STATISTICA (data analysis software system), version 8.0 (2007). 

View

 

Teo SD, Stirling S, Thomas A, Kiorpes A, Vikram K (2002). A 90-day oral gavage toxicity study of D-methylphenidate and D, L methylphenidate in Sprague-dawley rats. Toxicology 179(3):183-196.
Crossref

 

Vaghasiya YK, Shukla VJ, Chanda SV (2011). Acute oral toxicity study of Pluchea arguta boiss extract in mice. J. Pharmacol. Toxicol. 6(2)113-123.
Crossref

 

World Health Organization (WHO) (2007). Department of technical cooperation for essential drugs and traditional medicine. Guidelines for assessing quality of herbal medicines with reference to contaminants and residues, Geneva, Switzerland.