Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

Evaluation of herbal cocktail used in the treatment of malaria on liver tissue of adult Wistar rats

Moronkeji Akinpelu
  • Moronkeji Akinpelu
  • Department of Clinical Laboratory, Baptist Medical Centre, Saki, Oyo State, Nigeria.
  • Google Scholar
Eze Ikechi Gerald
  • Eze Ikechi Gerald
  • Department of Anatomy, University of Benin, Benin, Nigeria.
  • Google Scholar
Bejide Ronald Ayodele
  • Bejide Ronald Ayodele
  • Department of Morbid Anatomy and Forensic medicine, Obafemi Awolowo University, Ile-ife, Nigeria.
  • Google Scholar
Anwara Ogbonnaya Akpu
  • Anwara Ogbonnaya Akpu
  • Federal Teaching Hospital, Ido-Ekiti, Ekiti State, Nigeria.
  • Google Scholar
Igunbor Michael Chuks
  • Igunbor Michael Chuks
  • Department of Medical Laboratory Science, University of Benin, Benin City, Nigeria.
  • Google Scholar


  •  Received: 17 August 2018
  •  Accepted: 17 September 2018
  •  Published: 25 November 2018

References

Abass AY, Muhammad I, Bilbis LS, Saidu Y, Onu A (2017). In vitro antimalarial activity of some Nigerianmedicinal plants. Journal of Pharmacognosy and Phytochemistry 6(6):885-888

 

Aiyeloja AA, Bello OA (2006). Ethnobotanical potentials of common herbs in Nigeria: A case study of Enugu state. Education Research and Reviews 1(1):16-22.

 

Ajala TO, Igwilo CI, Oreagba IA, Oluwatoyin, Odeku OA (2011). The antiplasmodial effect of the extracts and formulated capsules of Phyllanthus amarus on Plasmodium yoelii infection in mice. Asian Pacific Journal of Tropical Medicine 4(4):283-287.
Crossref

 

Akin-Osaniye BC, NokAJ, Ibrahim S, Inuwa HM, Onyike E, AmLabu E, Haruna E (2013). "Antimalarial effect of Neem leaf and Neem stem bark extracts on Plasmodium berghei infected in the pathology and treatment of malaria". International Journal of Research in Biochemistry and Biophysics 3(1):7–14.

 

Al-Snafi AE (2016). Nutritional value and pharmacological importance of citrus species grown in Iraq. IOSR Journal of Pharmacy 6(8):76-108
Crossref

 

Anjum V, Ansari SH, Naquvi KJ, Arora P, Ahmad A (2013). Development of quality standards of Carica papaya Linn. Leaves. Scholars Research Library 5(2):370-376.

 

Anyaehie UB (2009). Medicinal properties of fractionated acetone/water neem (A. indica) leaf extract from Nigeria: A review. Nigerian Journal of Physiological Sciences 24:157-159.

 

Arise RO, Malomo SO, Lawal MM (2012). Comparative antimalarial and toxicological effects of artemisinin with methanolic extract of C. papaya leaves and bark of Alstonia broonai in animal models. Advances in Natural and Applied Sciences 6(2):116-123.

 

Arzoo and Parina K (2017). A review on plants having antimalarial activity. International Journal of Universal Pharmacy and Bio Sciences 6(3):142-158.

 

Avwioro OG (2014). Histochemistry and tissue pathology; Principles and Techniques. 3rdEdition. Society for Cellular Pathology Scientist of Nigeria pp. 97-98.

 

Dhar RH, Dawar S, Garg S, Basir F, Talwar GP (1996). "Effect of volatiles from neem and other natural products on gonotrophic cycle and oviposition of anopheles stephensi and An. Culicifacies (Diptera: Culicidae)". Journal of Medical Entomology 33(2):195-201.
Crossref

 

Ediriweera MK, Tennekoon KH, Samarakoon SR (2017). A review on ethnopharmacological applications, pharmacological activities, and bioactive compounds of Mangifera indica (Mango) Evidence-Based Complementary and Alternative Medicine pp. 1-24.
Crossref

 

Ene AC, Atawodi SE (2012). Ethnomedicinal survey of plantsused by the Kanuris of North-eastern Nigeria. Indian Journal of Traditional Knowledge 11(4): 640-645.

 

Etuk EU, Bello SO, Isezuo SA, Mohammed BJ (2010). Ethnobotanicalsurvey of medicinal plants used for the treatment ofDiabetes mellitus in the north western region of Nigeria. Asian Journal of Experimental Biological Sciences 1(1):55-59.

 

Evans WC (2002). Trease and Evans Pharmacognosy, 15th Edition. London: W.B. Sanders. pp. 183-393.

 

Fatmawaty F, Astuti H (2013). Antimalarial activity of Delonix regia on mice with Plasmodium berghei. Journal of Natural Products 6: 61-66.

 

Fatmawaty F, Rosmalena R, Amalia A, Syafitri I, Prasasty VD (2017). Antimalarial effect of flamboyant (Delonix regia) bark and papaya (C. papaya L) leaf ethanolic extracts against Plasmodium berghei in mice. Biomedical and Pharmacology Journal 10(3):1081-1089.
Crossref

 

Federal Ministry of Health (2015). National Malaria Elimination Programme, FMOH. Federal republic of Nigeria. Abuja, Nigeria.

 

Gbolahan WA, Titus AOl, Isiaka AA, Gbolahan-Ayoade EE (2014). Composition of some traditional malaria remedies and their antiplasmodial effects on (Plasmodium berghei). International Journal of Scientific Research Publications 4(3):1-8.

 

Grant GH (1987). Amino Acids and Proteins. In: Fundamentals of Clinical Chemistry, Tietz NW, 3rd edition, Philadephia, USA: WB Saunders Company pp. 328-329.

 

Ibrahim HA, Imam IA, Bello AM, Umar U, Muhammad S, Abdullahi SA (2012). The potential of Nigerian medicinal plant as antimalarial agent: A review. International Journal of Science and Technology 2(8):600-605.

 

Idowu OA, Soniran OT, Ajana O, Aworinde DO (2010). Ethnobotanical survey of antimalarial plants used in Ogun State, Southwest Nigeria. African Journal or Pharmacy and Pharmacology 4(2):55-60.

 

Innocent AE, Aniekan IP, Aquaisua NA (2017). Histopathological effect of Nauclea latifolia ethanolic leaf extract and Artemether/Lumefantrine on the hippocampus of P. berghei-infected mice. International Journal of Brain and Cognitive Sciences 6(1):9-16.

 

Ivanova D, Genova D, Chervenkov T, Yankova T (2005). Polyphenols and antioxidant capacity of Bulgarian medicinal plants. Journal of Ethnopharmacology 96(1-2):145-150.
Crossref

 

Iyamah PC, Idu M (2015). Ethnomedicinal survey of plants used in the treatment of malaria in Southern Nigeria. Journal of Ethnopharmacology 173:287-302.
Crossref

 

Laudicina VA, Palazzolo E, Germanà MA (2013). Current and Potential Use of Citrus Essential Oils. Current Organic Chemistry 17:3042-3049
Crossref

 

Longdet I, Emmanuel AA (2017). Effect of Methanolic leaf extract of C. papayaon Plasmodium berghei infection in Albino Mice. European Journal of Medicinal Plants 20(1): 1-7.
Crossref

 

Makni M, Jemai R, Kriaa W, Chtourou Y, Fetoui H (2018). Citrus limon from Tunisia: Phytochemical and physicochemical properties and biological activities. BioMed Research International pp. 1-8.
Crossref

 

Melariri P, Campbell W, Etusim P, Smith P (2012). In vitro antiplasmodial activities of extracts from five plants used singly and in combination against Plasmodium falciparum parasites. Journal of Medicinal Plants Research 6(47):5770-5779.

 

Mulla MS, Su T (1999). Activity and biological effects of Neem products against arthropods of medical and veterinary importance. Journal of the American Mosquito Control Association 15 (2):133-152.

 

Nathan SS, Kalaivani K, Muruga K (2005). Effects of Neem limonoids on the malaria vector Anopheles stephensi Liston (Diptera: Culicidae). Acta Tropica 96(1):47-55.
Crossref

 

Nayan V, Onteru SK, Singh D (2017). Mangifera indica flowerextract mediated biogenic green gold nanoparticles: Efficientnanocatalyst for reduction of 4-nitrophenol. Environmental Progress and Sustainable Energy 37(1):283-294.
Crossref

 

Noronha M, Guleria S, Jani D, George LB, Highland H, Subramanian RB (2018). Ethnobotanical database based screening and identification of potential plant species with antiplasmodial activity against chloroquine-sensitive (3D7) strain of Plasmodium Falciparum. Asian Pacific Journal of Tropical Biomedicine 8(2):92-97.
Crossref

 

Odugbemi TO, Akinsulire OR, Aibinu IE, Fabeku PO (2007). Medicinal plants useful for malarial therapy in Okeigbo, Ondo State, Southwest Nigeria. African Journal of Traditional. Complementary and Alternative Medicine 4(2):191-198.

 

Okere SO, Janet OS, Eunice O, Moses DA, Mercy OS (2014). Antiplasmodial activity of aqueous leaf extract of Cymbopogon citratus against Plasmodium falciparum infected rats. American Journal of Biomedical and Life Sciences 2(3):60-64 
Crossref

 

Okpe O, Nathan H, Joseph I, Vicent AU, Stanley IR, Okoduwa, Omiagocho TI (2016). Antimalarial potential of C. papaya and Vernonia amygdalina in mice infected with Plasmodium berghei. Journal of Tropical Medicine pp. 1-6.
Crossref

 

Olayode AA, Ofusori DA, Ogunniyi TA, Olusola SS, Bejide RA, Adelodun ST (2017). Modulatory role of aqueous leave extracts of M. indica (Linn) on liver function test in plasmodium - infected albino mice. Anatomy Physiology and Biochemistry International Journal 2(2): 001-005. 
Crossref

 

Olayode AA, Ofusori DA, Ogunniyi TAB, Olusola SS (2015). Histomorphological studies of the liver of Plasmodium-infected albino mice after administration of aqueous leaf extract of M. indica (Linn.). Anatomy 9(3).

 

Peter IT, Anatoli VK (1998). The current global malaria situation. Malaria parasite biology, pathogenesis and protection. Washington D.C, USA: ASM Press pp. 11-12.

 

Randrianarivelojosia M, Rasidimanana VT, Rabarison H, Cheplogoi PK, Ratsimbason M, Mulholland DA, Mauclère P (2003). Plants traditionally prescribed to treat tazo (malaria) in the eastern region of Madagascar. Malaria Journal 2:25.
Crossref

 

Reitman S, Frankel S (1957). A colorimetric method for determination of serum glutamate oxaloacetate and glutamic pyruvate transaminase. American Journal of Clinical Pathology 28:56-58.
Crossref

 

Saganuwan SA, Onyeyili PA, Etuk EU (2104). Immunomodulatory potentials and histopathological effects of aqueous leaf extracts of Abrus precatorius leaf in mus musculus. Journal of Haematology Research 1(2):54-62.

 

Sofowora A (1982). Medicinal plants and traditional medicine in Africa. John Wiley and sons Ltd.

 

Taek MM, Bambang PEW, Mangestuti A (2018). Ethnomedicinal plants used for the treatment of malaria in Malaka, West Timor. Journal of Young Pharmacists 10(2).
Crossref

 

Thomas EI, Vandebroek SS, Van Damme P (2009). Cultural significance of medicinal plant families and species among Quechua farmers in Apillapampa, Bolivia. Journal of Ethnopharmacology 122:60-67.
Crossref

 

Tietz NW (1995). Clinical guide to laboratory tests. 3rd Edition. Philadephia USA: WB Saunders Company pp. 518-519.

 

TitanjiV PK, Zofou D, Ngemenya MN (2008). The antimalarial potential of medicinal plants used for the treatment of malaria in cameroonian folk medicine. African Journal of Traditional Complementary and Alternative Medicine 5(3):302-321.

 

Tiwari R, Amit KV, Sandip C, Kuldeep D, Shoor VS (2014). Neem (Azadirachta. indica) and its potential for safeguarding health of animals and humans: A Review. Journal of Biological Sciences 14(2):110-123.
Crossref

 

Vaghasiya Y, Dave R, Chanda S (2011). Phytochemical analysis of some medicinal plants from western Region of India. Research Journal of Medicinal Plant 5(5):567-576.
Crossref

 

Vineet K, Upma B (2014). Structural changes in spleen architecture upon Plasmodium berghei (NK-65) infection in BALB/c mice. Journal of Pharmacy and Biological Sciences 9(4):16-20.
Crossref

 

Whitten R, Milner DAJr, Yeh MM, Kamiza S, Molyneux ME, Taylor TE (2011). Liver pathology in Malawian children with fatal encephalopathy. Human Pathology 42:1230-1239.
Crossref

 

World Health Organization (2005). World Malarial Report. Geneva. Malaria prevention and control.ISBN 92 4 159319 9 

 

World Health Organization (2014). World Malaria Report.Geneva. ISBN 978 92 4 156483 0.

View

 

World Health Organization. (2016). World Malaria Report.Geneva.ISBN 978-92-4-151171-1 

View

 

Yogiraj V, Goyal PK, Chauhan CS, Goyal A, Vyas B (2014). Carica papaya Linn: an overview. International Journal of Herbal Medicine 2(5): 01-08.