Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3626

Full Length Research Paper

Comparative analysis of capsaicin in twenty nine varieties of unexplored Capsicum and its antimicrobial activity against bacterial and fungal pathogens

Morrine A. Omolo
  • Morrine A. Omolo
  • Department of Food Science and Nutrition, University of Minnesota, Twin Cities, St. Paul, MN, USA.
  • Google Scholar
Zen-Zi Wong
  • Zen-Zi Wong
  • Department of Food Science and Nutrition, University of Minnesota, Twin Cities, St. Paul, MN, USA.
  • Google Scholar
Weih G. Borh
  • Weih G. Borh
  • Department of Chemistry, Augsburg College, Minneapolis, MN, USA.
  • Google Scholar
Grant A. Hedblom
  • Grant A. Hedblom
  • Department of Food Science and Nutrition, University of Minnesota, Twin Cities, St. Paul, MN, USA.
  • Google Scholar
Kamal Dev
  • Kamal Dev
  • Department of Food Science and Nutrition, University of Minnesota, Twin Cities, St. Paul, MN, USA.
  • Google Scholar
David J. Baumler
  • David J. Baumler
  • Department of Food Science and Nutrition, University of Minnesota, Twin Cities, St. Paul, MN, USA.
  • Google Scholar


  •  Received: 21 August 2018
  •  Accepted: 05 October 2018
  •  Published: 10 December 2018

References

Ahmed SA, Gogal RM, Walsh JE (1994). A new rapid and simple non-radioactive assay to monitor and determine the proliferation of lymphocytes: an alternative to [3H]thymidine incorporation assay. Journal of Immunological Methods 170(2):211-224.
Crossref

 

Al Othman ZA, Ahmed YBH, Habila MA, Ghafar AA (2011). Determination of capsaicin and dihydrocapsaicin in Capsicum fruit samples using high performance liquid chromatography. Molecules 16(10):8919-8929.
Crossref

 

Bacon K, Boyer R, Denbow C, O'Keefe S, Neilson A, Williams R (2017). Antibacterial activity of jalapeno pepper (Capsicum annuum var. annuum) extract fractions against select foodborne pathogens. Food Science and Nutrition 5(3):730-738.
Crossref

 

Bacon K, Boyer R, Denbow C, O'Keefe S, Neilson A, Williams R (2017). Evaluation of different solvents to extract antibacterial compounds from jalapeno peppers. Food Science and Nutrition 5(3):497-503.
Crossref

 

Barbero GF, Palma M, Barroso CG (2006). Pressurized liquid extraction of capsaicinoids from peppers. Journal of Agricultural and Food Chemistry 54(9):3231.
Crossref

 

Beacon Analytical Systems Inc. (2011). Capsaicin Plate Kit Cat.# 20-0072 Instructional Booklet. [updated 2011; cited 2015 06/12]; 

 

Borman AM, Szekely A, Johnson EM (2016). Comparative pathogenicity of United Kingdom ISOLATES of the emerging pathogen Candida auris and other key pathogenic candida species. MSphere 1(4):1-4.
Crossref

 

Brito-Argaez L, Moguel-Salazar F, Zamudio F, Gonzalez-Estrada T, Islas-Flores I (2009). Characterization of a Capsicum chinense seed peptide fraction with broad antibacterial activity. Asian Journal of Biochemistry 4(3):77-87.
Crossref

 

Byth HA, McHunu BI, Dubery IA, Bornman L (2001). Assessment of a simple, non-toxic alamar blue cell survival assay to monitor tomato cell viability. Phytochemical Analysis 12(5):340-346.
Crossref

 

Cichewicz RH, Thorpe PA (1996). The antimicrobial properties of chile peppers (Capsicum species) and their uses in Mayan medicine. Journal of Ethnopharmacolgy 52(2):61-70.
Crossref

 

Corson TW, Crews CM (2007). Molecular understanding and modern application of traditional medicines: triumphs and trials. Cell 130(5):769-774.
Crossref

 

Dorantes L, Araujo J, Carmona A, Hernandez-Sanchez H (2008). Effect of capsicum extracts and cinnamic acid on the growth of some important bacteria in dairy products. Food Engineering Series pp. 337-344.
Crossref

 

Dorantes L, Colmenero R, Hernandez H, Mota L, Jaramillo ME, Fernandez E (2000). Inhibition of growth of some foodborne pathogenic bacteria by Capsicum annum extracts. International Journal of Food Microbiology 57(1-2):125-128.
Crossref

 

Fai PB, Grant A (2009). A rapid resazurin bioassay for assessing the toxicity of fungicides. Chemosphere 74(9):1165-1170.
Crossref

 

Gloeckner H, Jonuleit T, Lemke HD (2001). Monitoring of cell viability and cell growth in a hollow-fiber bioreactor by use of the dye Alamar Blue. Journal of Immunological Methods 252(1-2):131-138.
Crossref

 

Guerin TF, Mondido M, McClenn B, Peasley B (2001). Application of resazurin for estimating abundance of contaminant-degrading micro-organisms. Letters in Applied Microbiology 32(5):340-345.
Crossref

 

Ibrahim MK, Galal A-MM, Al-Turk IM, Al-Zhrany KD (2010). Antibiotic resistance in Gram-negative pathogenic bacteria in hospitals' drain in Al-Madina Al-Munnawara. Journal of Taibah University for Science 3(1):14-22.
Crossref

 

Kantar MB, Anderson JE, Lucht SA, Mercer K, Bernau V, Case KA (2016). Vitamin Variation in Capsicum Spp. Provides Opportunities to Improve Nutritional Value of Human Diets. PLoS One 11(8):e0161464.
Crossref

 

Kurita S, Kitagawa E, Kim C-H, Momose Y, Iwahashi H (2002). Studies on the antimicrobial mechanisms of capsaicin using yeast DNA microarray. Bioscience, Biotechnology and Biochemistry 66(3):532-6.
Crossref

 

Ling F, Wang JG, Lu C, Wang GX, Lui YH, Gong XN (2012). Effects of aqueous extract of Capsicum frutescens (Solanaceae) against the fish ectoparasite Ichthyophthirius multifiliis. Parasitology Research 111(2):841-848.
Crossref

 

Liu D (1989). Assessment of the interaction between microorganism and chemical mixture using resazurin reduction. Toxicity Assessment 4(4):463-471.
Crossref

 

Mariscal A, Lopez-Gigosos R, Carnero-Varo M, Fernandez-Crehuet J (2009). Fluorescent assay based on resazurin for detection of activity of disinfectants against bacterial biofilm. Applied Microbiology and Biotechnology 82(4):773-783.
Crossref

 

Meghvansi MK, Siddiqui S, Khan MH, Gupta VK, Vairale MG, Gogoi HK (2010). Naga chilli: a potential source of capsaicinoids with broad-spectrum ethnopharmacological applications. Journal Ethnopharmacology 132(1):1-14.
Crossref

 

Mills-Robertson FC, Tay SCK, Duker-Eshun G, Walana W, Badu K (2012). In vitro antimicrobial activity of ethanolic fractions of Cryptolepis sanguinolenta. Annals of Clinical Microbiology and Antimicrobials 11(1):1-7.
Crossref

 

O'Brien J, Wilson I, Orton T, Pognan F (2000). Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity. European Journal of Biochemistry 267(17):5421-5426.
Crossref

 

Omolo MA, Wong ZZ, Mergen AK, Hastings JC, Le NC, Reiland HA (2014). Antimicrobial Properties of Chili Peppers. Journal of Infectious Diseases & Therapy 2(4):1-8.
Crossref

 

Paul W, Bosland DC, Reeves G (2012). 'Trinidad Moruga Scorpion' Pepper is the World's Hottest Measured Chile Pepper at More Than Two Million Scoville Heat Units. HortTechology 22(4):534-538.

 

Perkins B, Bushway R, Guthrie K, Fan T, Stewart B, Prince A (2002). Determination of capsaicinoids in salsa by liquid chromatography and enzyme immunoassay. Journal of AOAC International 85(1):82-85.

 

Promega Corporation (2016). CellTiter-Blue Cell Viability Assay [updated 2016; cited 2017 01/21]; 

View

 

Rampersad SN (2012). Multiple applications of alamar blue as an indicator of metabolic function and cellular health in cell viability bioassays. Sensors 12(9):12347-12360.
Crossref

 

Rollyson WD, Stover CA, Brown KC, Perry HE, Stevenson CD, McNees CA (2014). Bioavailability of capsaicin and its implications for drug delivery. Journal of Controlled Release 196:96-105.
Crossref

 

Sanatombi K, Sharma GJ (2008). Capsaicin Content and Pungency of Different Capsicum spp. Cultivars. Notulae Botanicae Horti Agrobotanici Cluj-Napoca 36(2):89-90.

 

Sarker SD, Nahar L, Kumarasamy Y (2007). Microtitre plate-based antibacterial assay incorporating resazurin as an indicator of cell growth, and its application in the in vitro antibacterial screening of phytochemicals. Methods 42(4):321-324.
Crossref

 

Sarwa KK, Das PJ, Mazumder B (2014). A nanovesicle topical formulation of Bhut Jolokia (hottest Capsicum): A potential anti-arthritic medicine. Expert Opinion on Drug Delivery 11(5):661-676.
Crossref

 

Sarwa KK, Mazumder B, Suresh PK, Kaur CD (2016). Topical Analgesic nanolipid vesicles formulation of capsaicinoids extract of bhut jolokia (Capsicum chinense Jacq): Pharmacodynamic evaluation in rat models and acceptability studies in human volunteers. Current Drug Delivery 13(8):1325-1338.
Crossref

 

Sittampalam G, Coussens N, Brimacombe K (2014). Assay Guidance Manual [Internet]. Bethesda (MD): Eli Lilly and Company and the National Center for Advancing Translational Sciences; [updated 2004; cited 2017 01/20]; 

View

 

Stewart C, Mazourek M, Stellari GM, O'Connell M, Jahn M (2007). Genetic control of pungency in C. chinense via the Pun1 locus. Journal of Experimental Botany 58(5):979-991.
Crossref

 

Twigg RS (1945). Oxidation-Reduction aspects of resazurin. Nature 155(3935):401-402.
Crossref

 

Vega-Avila E, Pugsley MK (2011). An overview of colorimetric assay methods used to assess survival or proliferation of mammalian cells. Proceedings of the Western Pharmacology Society 54:10-4.

 

Węsierska-Gądek J, Gueorguieva M, Ranftler C, Zerza-Schnitzhofer G (2005). A new multiplex assay allowing simultaneous detection of the inhibition of cell proliferation and induction of cell death. Journal of Cellular Biochemistry 96(1):1-7.
Crossref

 

Zhi-Jun Y, Sriranganathan N, Vaught T, Arastu SK, Ahmed SA (1997). A dye-based lymphocyte proliferation assay that permits multiple immunological analyses: mRNA, cytogenetic, apoptosis, and immunophenotyping studies. Journal of Immunological Methods 210(1):25-39.
Crossref