Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

Evaluation of antidiabetic activity of the ethanol extract of Momordica charantia L. and the identification of charantine by gas chromatography coupled with Mass spectrometry

Snelle Miakayizila Baonda
  • Snelle Miakayizila Baonda
  • Unit of Chemistry of Plant and of the Life, Faculty of Sciences and Technology Marien N’GOUABI University, B.P. 69, Brazzaville Congo.
  • Google Scholar
Celestine Nkounkou Loumpangou
  • Celestine Nkounkou Loumpangou
  • Unit of Chemistry of Plant and of the Life, Faculty of Sciences and Technology Marien N’GOUABI University, B.P. 69, Brazzaville Congo.
  • Google Scholar
Raoul Ampa
  • Raoul Ampa
  • Unit of Chemistry of Plant and of the Life, Faculty of Sciences and Technology Marien N’GOUABI University, B.P. 69, Brazzaville Congo.
  • Google Scholar
Arnold Murphy Elouma Ndinga
  • Arnold Murphy Elouma Ndinga
  • Unit of Chemistry of Plant and of the Life, Faculty of Sciences and Technology Marien N’GOUABI University, B.P. 69, Brazzaville Congo.
  • Google Scholar
Longin Justin Clair Bonazaba Milandou
  • Longin Justin Clair Bonazaba Milandou
  • Unit of Chemistry of Plant and of the Life, Faculty of Sciences and Technology Marien N’GOUABI University, B.P. 69, Brazzaville Congo.
  • Google Scholar
Myriam Bonose
  • Myriam Bonose
  • Paris sud university, lip (Sys)2, LETIAM, IUT of Orsay, Plateau de moulon, 91400 Orsay, France.
  • Google Scholar
Jean Maurille Ouamba
  • Jean Maurille Ouamba
  • Unit of Chemistry of Plant and of the Life, Faculty of Sciences and Technology Marien N’GOUABI University, B.P. 69, Brazzaville Congo.
  • Google Scholar


  •  Received: 22 February 2019
  •  Accepted: 03 June 2019
  •  Published: 25 July 2019

References

Adjanohoun EJ, Ahyi AM, Ake AJ, Baniakissa J, Chibon P, Cusset G, Doulou V, Eutanga A, Eyme J, Goudote E, Keïta A, Mbemba C, Mollet J, Moutsambote JM, Mpati J, Sita P (1988). Contribution to ethnobotanical and floristic studies in Peoples Republic of Congo. Paris: Traditional Medicine and pharmacopoeia. Brazzaville: Contribution to ethnobotanical and floristic studies in Peoples Republic of Congo. Paris: TACCT (Cultural and Technical Cooperation Agency).

 

Ahamad J, Amin S, Mir SR (2014). Development and validation of HPTLC densitometric method for estimation of charantin in Momordica charantia fruits and herbal formulation. Journal of Pharmacognosy and Phytochemistry 2:172-176.

 

Ahombo G, Ampa R, Diatewa M, Mpati J, Abena AA, Ouamba JM (2012). Investigating on related diabetes therapeutic plants used in traditional medicine at Brazzaville. Journal of Medicinal Plants Research 44:5630-5639.

 

Altman JJ, Ducloud R, Dutel LL (2012). Le grand livre du diabète. paris: Eyrolles.

 

Andrade-Cetto A, Wiedenfeld H, Revilla-Monsalve, MC Islas S (2000). Hypoglycemic effect of Equisetum myriochaetum aerial parts on streptozotocin diabetic rat. Journal of Ethnopharmacology (72):129-133.
Crossref

 

Cantwell M, Nie X, Zong Ru J, Yamaguchi M (1996). Cantwell M, Nie X, Zong Ru J, Yamaguchi M (1996). Asian vegetables: Selected fruit and leafy types. Progress in new crops. ASHS Press, Arlington pp. 488-495.

 

Coskun O, Kanter M, Korkmaz A, Oter S (2005). Quercetin, flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and cell damage in rat pancreas. Pharmacological Research 51:117-123.
Crossref

 

Day C, Cartwright T, Provost T, Bailey C (1990). Hypoglycemic effect of Momordica charantia extracts. Planta Medica 56(05):426-429.
Crossref

 

Cho NH, Shaw JE, Karuranga S, Huang Y, da Rocha Fernandes JD, Ohlrogge AW, Malanda B (2018). IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Research and Clinical Practice 138:271-281.
Crossref

 

Goad J, Akihisa T (1997). Analysis of Sterols. Blackie and professional an imprint of Chapman and Hall. P 438.
Crossref

 

Haixia Z, Xiaozuo Z, Yawei W, Mancanq L, Zhide H (2004). Analysis of vicine in bitter melon samples by polyglycol-C8 solid phase with high performance liquid chromatography. Chinese Journal of Analytical Chemistry 3:408-108.

 

Han C, Hui Q, Wang Y (2008). Hypoglycaemic activity of saponin fraction extracted from Momordica charantia in PEG/salt aqueous two-phase systems. Natural Products Research 22:1112-1119.
Crossref

 

Jaffiol C (2011). Le diabète sucré en Afrique: un enjeu de santé publique. Bulletin de l'Académie nationale de médecine. 195(6):1239-1253.
Crossref

 

Jesada P, Sutawadee C, Motonobu G, Weena J, Mitsuru S, Artiwan S (2007). New approach for extraction of charantin from Momordica charantia with pressurized liquid extraction. Separation and Purification Technology 52(3):416-422. 
Crossref

 

Kedar P, Chakrabarti CH (1982). Effects of bittergourd (Momordica charantia) seed and glibenclamide in streptozotocin induced diabetes mellitus. Indian Journal of Experimental Biology 20:232-235.

 

Khodadadi S (2016). Administration of Galega officinalis in experimental and clinical investigations. Annals of Research in Antioxidants 1:1.

 

Kimura Y, Akihisa T, Yuasa N, Ukiya M, Suzuki T, Toriyama M, Motohashi S, Tokuda H (2005). Cucurbitane-type triterpenoids from the fruit of Momordica charantia. Journal of Natural Products 68:807-809.
Crossref

 

Lalèyè OAF, Ahissou H, Assogba MF, Azando VBE, Olounladé AP, Agbo'Saga KF, Lalèyè A (2015). In vivo hypoglycemic activity and acute oral toxicity of ethanolic and aqueous leaves extract of Momordica charantia Linn (Cucurbitaceae) from Benin. Journal of Chemistry and Pharmaceutical Research 7:376-385.

 

Majekodunmi F, Takeda Y, Yamashit H, Okabe H, Yamauchi T (1990). New cucurbitane triterpenoids from Momordica charantia. Journal of Natural Products 53:1491-1497.
Crossref

 

Nagy MA, Bastawy MA, Abdel-Hamid NM (2012). Effects of Momordica Charantia on Streptozotocin-Induced Diabetes in Rats: Role of Insulin, Oxidative Stress and Nitric Oxide. Journal of Health Science 2:8-13.
Crossref

 

Neha L, Priyanka S, Aashish P (2016). Role of Flavonoids and Saponins in the Treatment of Diabetes Mellitus. Journal of Pharmaceutical Science and Bioscientific Research 6:535-541.

 

Phillips KM, Ruggio DM, Ashraf-khorassani M (2005). Analysis of steryl glucosides in foods and dietary supplements by solid-phase extraction and gas chromatography. Journal of Food Lipids 12:124-140.
Crossref

 

Pitiphanpong J, Chitprasert S, Goto M, Jiratchariyakul W, Sasaki M, Shotipruk A (2007). A New approach for extraction of charantin from Momordica charantia with pressurized liquid extraction. Separation and Purification Technology 52(3):416-422.
Crossref

 

Sabira B, Mansoor A, Bina S, Siddiqui AK, Zafar S, Saify MA (1997). Triterpenes, a sterol, and a monocyclic alcohol from Momordica charantia. Journal of Phytochemistry 44:1313-1320.
Crossref

 

Sakine MNA, Mahmout Y, Gbenou J, Agbodjogbe W, Moudachirou M (2014). Inventaire ethnobotanique des plantes du Tchad utilisées contre le diabète: effet antihyperglycémiant des extraits de Boscia senegalensis (Pers.) Lam. ex Poiret et de Colocynthis vulgaris (Schrad.). Phytothérapie 9:268-273.
Crossref

 

Schmelzer GH, Gurib-Fakim A (2008). Ressources végétales de l'Afrique tropicale. Plantes médicinales 11(1).

 

Singh R, Kumar A, Giri DD, Bhuvaneshwari K, Pandey KD (2012). Gas Chromatogrphy-Mass Spectrometry Analysis and Phytochemical Screening of Methanolic Fruit Extract of Momordica charantia. Journal of Recent Advances in Agriculture 1(4):122-127.

 

Sonal D, Pratima T (2015). Charantin: An important lead compound from Momordica charantia for the treatment of diabetes. Journal of Pharmacognosy and Phytochemistry 3:163-166.

 

Thomas CT, Padmanabha RY, Devanna N (2012). Impact of cooking on charantin estimated from bitter melon fruits using high performance thin layer chromatography. International Research Journal of Pharmacy 2:149-154.

 

Wang HY, Kan WC, Cheng TJ, Yu SH, Chang LH, Chuu JJ (2014). Differential anti-diabetic effects and mechanism of action of charantin-rich extract of Taiwanese Momordica charantia between type 1 and type 2 diabetic mice. Food and Chemical Toxicology 69:347-356.
Crossref