Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

The effect of Thymus vulgaris L. on renal and liver toxicity in wistar rats exposed to aluminum

Nawel Mokrane
  • Nawel Mokrane
  • Laboratory of Experimental Biotoxicology, University of Ahmed Ben Bella “1”, Oran, Algeria.
  • Google Scholar
Omar Kharoubi
  • Omar Kharoubi
  • Laboratory of Experimental Biotoxicology, University of Ahmed Ben Bella “1”, Oran, Algeria.
  • Google Scholar
Fatima Zohra Tahari
  • Fatima Zohra Tahari
  • Laboratory of Experimental Biotoxicology, University of Ahmed Ben Bella “1”, Oran, Algeria.
  • Google Scholar
Akila Guenzet
  • Akila Guenzet
  • Laboratory of Clinic and Metabolic Nutrition, University of Ahmed Ben Bella “1”, Oran, Algeria.
  • Google Scholar
Abdelkader Aoues
  • Abdelkader Aoues
  • Laboratory of Experimental Biotoxicology, University of Ahmed Ben Bella “1”, Oran, Algeria.
  • Google Scholar


  •  Received: 15 July 2019
  •  Accepted: 08 November 2019
  •  Published: 31 January 2020

References

Abd El Kader MA, Mohamed NZ (2012). Evaluation of protective and antioxidant activity of thyme (Thymus Vulgaris) extract on paracetamol-induced toxicity in rats. Australian Journal of Basic and Applied Sciences 6(7):467-474.
 
Alam K, Nagi MN, Badary OA, AL-Shabanah OA, Al-Rikabi AC, Al-Bekairi AM (1999). The protective action of thymol against carbon tetrachloride hepatotoxicity in mice. Pharmacological Research 40(2):159-163.
Crossref
 
Al-Asmari AK, Athar T, Al-Faraidy AA, Almuhaiza MS (2017). Chemical composition of essential oil of Thymus vulgaris collected from Saudi Arabian market. Asian Pacific Journal of Tropical Biomedicine 7(2):147-150
Crossref
 
Al-Qhtani SA, Farran SK (2017). The Protective and therapeutic effect of resveratrol in improving renal and hepatic failure induced by aluminum chloride in experimental animals. Journal of American Science 13(10).
 
Amiri H (2012). Essential oils composition and antioxidant properties of three Thymus species. Evidence-Based Complementary and Alternative Medicine 2012: 8.
Crossref
 
Balgoon MJ (2019). Assessment of the protective effect of Lepidium sativum against aluminum-induced liver and kidney effects in albino rat. BioMed Research International .
Crossref
 
Belaïd-Nouira Y, Bakhta H, Haouas Z, Flehi-Slim I, Ben Cheikh H (2013). Fenugreek seeds reduce aluminum toxicity associated with renal failure in rats. Nutrition Research and Practice 7(6):466-474.
Crossref
 
Benabed KH, Gourine N, Ouinten M, Bombarda I, Yousfi M (2018). chemical composition, antioxidant and antimicrobial activities of the essential oils of three algerian lamiaceae species. Current Nutrition and Food Science 13(2):97-109.
Crossref
 
Benyettou I, Kharoubi O, Hallal N, Benyettou HA, Tair K, Belmokhtar M, Aoues A, Ozaslan M (2017). Aluminium-induced behavioral changes and oxidative Stress in developing rat Brain and the possible ameliorating role of omega-6/omega-3 ratio. Journal of Biological sciences 17(3): 106-117.
Crossref
 
Bondy SC (2010). The neurotoxicity of environmental aluminum is still an issue. Neurotoxicology 31(5):575-581.
Crossref
 
Chappard D, Bizot P, Mabilleau G, Hubert L (2016). Aluminum and bone: Review of new clinical circumstances associated with Al(3+) deposition in the calcified matrix of bone. Morphologie 100(329):95-105.
Crossref
 
Cheng D, Zhu C, Wang C, Xu H, Cao J, Jiang W (2014). Hepatoprotective effects of apple polyphenol extract on aluminum-induced liver oxidative stress in the rat. Canadian Journal of Physiology and Pharmacology 92:109-116.
Crossref
 
Crichton S, Wilmet R, Legssyer l (2002). Molecular and cellular mechanisms of iron homeostasis and toxicity in mammalian cells. Journal of Inorganic Biochemistry 91(1):9-18.
Crossref
 
Dapkevicius A, van Beek TA, Lelyveld GP, van Veldhuizen A, de Groot Ae, Linssen JPH, Venskutonis R (2002). Isolation and structure elucidation of radical scavengers from Thymus vulgaris leaves. Journal of Natural Products 65(6):892-896.
Crossref
 
Ecelbarger CA, MacNeil GG, Greger JL (1994). Aluminum retention by aged rats fed aluminum and treated with desferrioxamine. Toxicology Letters 73(3):249-57.
Crossref
 
El-Demerdash FM (2004). Antioxidant effect of vitamin E and selenium on lipid peroxidation, enzyme activities and biochemical parameters in rats exposed to aluminum. Journal of Trace Elements in Medicine and Biology 18(1):113-121.
Crossref
 
El-Nekeety AA, Mohamed SR, Hathout AS, Hassan NS, Aly SE, Abdel-Wahhab MA (2011). Antioxidant properties of Thymus vulgaris oil against aflatoxin-induce oxidative stress in male rats. Toxicon 57(7-8):984-991.
Crossref
 
El-Newary SA, Shafie NM, Omer EA (2017). The protection of Thymus vulgaris leaves alcoholic extract against hepatotoxicity of alcohol in rats. Asian Pacific Journal of Tropical Medicine 10(4):361-371.
Crossref
 
El-Sayed WM, Al-Kahtania MA, Abdel-Moneima AM (2011). Prophylactic and therapeutic effects of taurine against aluminum-induced acute hepatotoxicity in mice. Journal of Hazardous Materials 192(2):880-886.
Crossref
 
Esmaeili MA, Sonboli A, Kanani MR, Sadeghi H (2000). Salvia sahendica prevents tissue damages induced by alcohol in oxidative stress conditions: Effect on liver and kidney oxidative parameters. Journal of Medicinal Plants Research 3(4):276-283.
 
Exley C (2004). The pro-oxidant activity of aluminum. Free Radical Biology and Medicine 36(3):380-387.
Crossref
 
Exley C (2016). The Toxicity of aluminum in humans. Morphologie 100(329):51-55.
Crossref
 
Geleta B, Debelo N, Afework M, Debella A, Makonnen E, Ergete W (2016). Assessment of Hematological, Biochemical and Histopathological effects of Acute and Sub-chronic administration of the Aqueous leaves extract of Thymus schimperi in Rats. Journal of Clinical Toxicology 6(2):286.
Crossref
 
Ghorbel I, Khemakhem M, Boudawara O, Marrekchi R, Jamoussi K, Ben Amar R, Boudawara T, Zeghal N, Grati Kamoun N (2015). Effects of dietary extra virgin olive oil and its fractions on antioxidant status and DNA damage in the heart of rats co-exposed to aluminum and acrylamide. Food and Function 6(9): 3098-3108.
Crossref
 
Gonzalez MA, Roma M, Bernal C, Alvarez ML, Carrillo MC (2004). Biliary Secretory function in Rats Chronically Intoxicated with Aluminum. Toxicological Sciences 79(1):189-195.
Crossref
 
Guo CH, Huang CJ, Chen ST, Hsu GSW (2001). Serum and testicular testosterone and nitric oxide products in aluminum-treated mice. Environmental Toxicology and Pharmacology 10(1-2):53-60.
Crossref
 
Guo CH, Lin CY, Yeh MS, Hsu GSW (2005). Aluminum-induced suppression of testosterone through nitric oxide production in male mice. Environmental Toxicology and Pharmacology 19(1):33-40.
Crossref
 
Hasona NA, Ahmed MQ (2017). Antioxidant and ameliorative effects of Zingiber Officinale against aluminum chloride toxicity. Science International 5(3):96-104.
Crossref
 
Hosseinzadeh S, Kukhdan AJ, Hosseini A, Armand R (2015). The application of Thymus vulgaris in traditional and modern medicine: A Review. Global Journal of Pharmacology 9(3):260-266.
 
Joshi DK, Choudhary M, Tripathi S, Singh Negi MP, Mahdi AA (2013). Age dependent relative risk of aluminum toxicity: levels of metals and enzymatic and non-enzymatic antioxidants status in liver, kidney and brain of aluminum treated young and old rats. International Journal of Biological and Pharmaceutical Research 4(3):176-185.
 
Kinawy AA (2019). Potential toxicity of aluminum and fluoride on some biochemical aspects of male rat's offspring. The Journal of Basic and Applied Zoology 80:18.
Crossref
 
Komaki A, Hoseini F, Shahidi S, Baharlouei N (2016). Study of the effect of extract of Thymus vulgaris on anxiety in male rats. Journal of Traditional and Complementary Medicine 6(3): 257-261.
Crossref
 
Kruck TP, Cui JG, Percy ME, Lukiw WJ (2004). Molecular shuttle chelation: the use of Ascorbate, Desferrioxamine and Ferelax-G in combination to remove nuclear bound aluminum. Cellular and Molecular Neurobiology 24(3):443-459.
Crossref
 
Kutlubay R, Oguz OE, Abban G, Turgut S (2007). Amelioration of aluminum-induced liver damage by vitamin E. Saudi Medical Journal 28 (2):197-200.
 
Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951). Protein measurement with the Folin phenol reagent. The Journal of Biological Chemistry 193(1):265-275.
 
Mahieu S, Contini MDC, González M, Millen N (2009). Melatonin reduces oxidative damage induced by Aluminum in rat kidney. Toxicology Letters 190(1):9-15.
Crossref
 
Manafi M, Hedayati M, Yari M (2014). Aflatoxicosis and herbal detoxification: The effectiveness of Thyme essence on performance parameters and antibody titers of commercial broilers fed aflatoxin B1. Research in Zoology 4(2):43-50.
 
Massoud AA, Hegazi MM, Hashem AA, Basuony NS (2016). Protective role and ameliorating effect of vitamin E in hepatic and renal functions of mice treated with aluminum chloride. Egyptian Journal of Experimental Biology 12(1):23-30.
 
Melidou M, Riganakos K, Galaris D (2005). Protection against nuclear DNA damage offered by flavonoids in cells exposed to hydrogen peroxide: the role of iron chelation. Free Radical Biology and Medicine 39(12):1591-1600.
Crossref
 
Missel JR, Schetinger MR, Gioda CR, Bohrer DN, Pacholski IL, Zanatta N, Martins MA, Bonacorso H, Morsch VM (2005). Chelating effect of novel pyrimidines in a model of aluminum intoxication. Journal of Inorganic Biochemistry 99(9):1853-1857.
Crossref
 
Mohamed HH, Abd Ali IK, Reshag AF (2017). Histological changes in the liver, kidney and spleen of White Albino Rat after Aluminum Chloride administration. The Iraqi Journal of Veterinary Medicine 41(2):1-6.
 
Monasterolo L, Peiretti A, Elias MM (1993). Rat renal functions during the first days post-bile duct ligation. Renal Failure 15(4):461-467.
Crossref
 
Nehru B, Bhalla P (2006). Reversal of an aluminum induced alteration in redox status in different regions of rat brain by administration of centrophenoxine. Molecular and cellular biochemistry 290(1-2):185-191.
Crossref
 
Newairy AS, Salama AF, Hussien HM, Yousef MI (2009). Propolis alleviates aluminum-induced lipid peroxidation and biochemical parameters in male rats. Food and Chemical Toxicology 47(6):1093-1098.
Crossref
 
Ochmanski W, Barabasz W (2000). Aluminum-occurrence and toxicity for organisms. Przeglad Lekarski 57(11):665-668.
 
Okhawa H, Ohishi N, Yagi K (1979). Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analytical Biochemistry 95(2):351-358.
Crossref
 
Paz LNF, Moura LM, Feio DCA, Cardoso MDSG, Ximenes WLO, Montenegro RC, Alves APN, Burbano RP, Lima PDL (2017). Evaluation of in vivo and in vitro toxicological and genotoxic potential of aluminum chloride. Chemosphere 175:130-137.
Crossref
 
Popovic-Milenkovic MT, Tomovic MT, Brankovic SR, Ljujic BT, Jankovic SM (2014). Antioxidant and anxiolytic activities of Crataegus nigra Wald. et Kit. Berries. Acta Poloniae Pharmaceutica 71(2):279-285.
 
Rahman MF, Siddiqui MK, Jamil K (2000). Acid and alkaline phosphatase activities in a novel phosphorothionate (RPR-11) treated male and female rats. Evidence of dose and time-dependent response. Drug and Chemical Toxicology 23(3):497-509.
Crossref
 
Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafema, DG, Hoekstra WG (1973). Selenium: biochemical role as a component of glutathione peroxidase. Science 179(4073): 588-590.
Crossref
 
Rudenko SS, Bodnar BM, Kukharchuk OL, Mahalias VM, Rybshchka MM, Ozerova IO, Chala KM, Khalaturnik MV (1998). Effect of selenium on the functional state of white rat kidney in Aluminum cadmium poisoning. Ukrainskii Biokhimicheskii Zhurnal 70(6):98-105.
 
Shati AA, Alamri SA (2010). Role of saffron (Crocus sativus L.) and honey syrup on aluminum-induced hepatotoxicity. Saudi Medical Journal 31(10):1106-1113.
 
Singla N, Dhawan DK (2013). Zinc protection against aluminum induced altered lipid profile and membrane integrity. Food and Chemical Toxicology 55:18-28.
Crossref
 
Sivakumar S, Khatiwada CP, Sivasubramanian J, Raja B (2014). FTIR study of protective action of deferoxamine and deferiprone on the kidney tissues of aluminum loaded mice. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 118:488-497.
Crossref
 
Somova LI, Missankov A, Khan MA (1997). Chronic aluminum intoxication in rats: dose-dependent morphological changes. Methods and Findings in Experimental and Clinical Pharmacology 19(9):599-604.
 
Tahari FZ, Lablack M, Ait hamadouche N, Tahari Z, Aoues A (2016). Protective effect of Haloxylon salicornicum on hepatic and renal functions of Wistar rats exposed to aluminum. African Journal of Biotechnology 15(9):293-302.
Crossref
 
Taïr K, Kharoubi O, Taïr OA, Hellal N, Benyettou I, Aoues A (2016). Aluminium-induced acute neurotoxicity in rats: Treatment with aqueous extract of Arthrophytum (Hammada scoparia). Journal of Acute Disease 5(6):470-482.
Crossref
 
Tripathi S, Mahdi AA, Nawab A, Chander R, Hasan M, Siddiqui MS, Mahdi F, Mitra K, Bajpai VK (2009). Influence of age on aluminum induced lipid peroxidation and neurolipofuscin in frontal cortex of rat brain: A behavioral, biochemical and ultrastructural study. Brain Research 1253:107-116.
Crossref
 
Tural S, Turhan S (2017). Antimicrobial and antioxidant properties of thyme (Thymus vulgaris L.), rosemary (Rosmarinus officinalis L.) and laurel (Lauris nobilis L.) essential oils and their mixtures. GIDA 42(5):588-596.
Crossref
 
Ündeger Ü, Bas aran A, Degen GH, Bas aran N (2009). Antioxidant activities of major thyme ingredients and lack of (oxidative) DNA damage in V79 Chinese hamster lung fibroblast cells at low levels of carvacrol and thymol. Food and Chemical Toxicology 47(8):2037-2043.
Crossref
 
Van Ginkel MF, van der Voet GB, de Wolf FA (1990). Improved method of analysis for aluminum in brain tissue. Clinical Chemistry 36(4):658-661.
Crossref
 
Viezeliene D, Jansen E, Rodoviciusc H, Kasauskas A, Ivanov L (2011). Protective effect of selenium on aluminum-induced oxidative stress in mouse liver in vivo. Environmental Toxicology and Pharmacology 31(2):302-306.
Crossref
 
Yang UJ, Park TS, Shim SM (2013). Protective effect of chlorophyllin and lycopene from water spinach extract on cytotoxicity and oxidative stress induced by heavy metals in human hepatoma cells Journal Toxicology and Environmental Health - Part A 76(23):1307-1315.
Crossref
 
Yeh YH, Lee YT, Hsieh HS, Hwang DF (2009). Effect of taurine on toxicity of aluminum in rats. e-SPEN. European e-Journal of Clinical Nutrition and Metabolism 4(4):187-192.
Crossref