Antimicrobial, antioxidant and cytotoxic activites and chemical profile of species of Miconia Ruiz & Pav., Clidemia D. Don and Tibouchina Aubl. (Melastomataceae)
The resistance of microorganisms to current antimicrobials, and the deleterious effects caused by the excessive free radical manufacturing in the human body and their relationship with increasing global incidence of cancer, has led to a continuous search for new chemical agents that can contribute to the fight against these ills. The objective of the present work was to evaluate the antimicrobial, antioxidant and...
Dominant lethal mutations in rats fed extracts of Mucuna urens (Linn.)
Dominant lethal mutation assay was carried out on rats after being treated with graded doses of ethanol extract of the seeds of Mucuna urens. Male albino rats (Wistar strain) were caged in three groups labeled, groups II, III and IV and treated with three different dosages of the ethanol extract of the seeds of M. urens; 70, 140 and 210 mg/kg body weight (BW), respectively, for 14 days. The positive control animals...
The effect of Thymus vulgaris L. on renal and liver toxicity in wistar rats exposed to aluminum
The main sources of human exposure to aluminum are found in the extensive presence of the metal in the environment and its growing industrial applications. The present study was carried out to determine the effectiveness of the Thymus vulgaris L. extract in alleviating aluminum chloride (AlCl3) toxicity on biochemical and antioxidant parameters. The experiment’s rats were divided into five groups: a control group;...
Advances in the research of Adenanthera pavonina: From traditional use to intellectual property
Adenanthera pavonina, an Asian native leguminous, is a well known highly used plant in traditional medicine. Such broad herbal medicine applications motivated several researchers to study its chemical composition, mainly of its leaves, seeds, and barks, besides the pharmacological effects aiming to demonstrate scientific evidence of its empirical uses. Most studies have been conducted with plant derivatives, and more...
Phytochemical screening and in vitro evaluation of antibacterial activity of aqueous and ethanolic extracts of root and stem bark of Bridelia ferruginea. Benth. (Euphorbiaceae)
This study aimed at analysing the phytochemical content and antimicrobial activity of Bridelia ferrugine against selected bacteria. Total saponin, alkaloids, tannins, flavonoids and total anthraquinone contents were evaluated using spectrophotometric equivalents of the standards. The antibacterial activity of the plant extracts were determined using Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal...