November 2016

Insignificant activity of Allium paradoxium and Tanacetum parthenium on protoscoleces of Echinococcus granulosus: In vitro study

Medicinal plants are now recognized as most important alternative for chemical drugs resource, especially for anti-microbial targets. The current study aimed to determine the scolicidal effect of Allium paradoxium and Tanacetum parthenium as medicinal plants in vitro. Protoscoleces were exposed to different concentrations of chloroformic and hydroalcholic extracts (1, 10, 50 and 100 mg/mL) for 5, 10, 30, 60 and 120 min....

Author(s): Elham Raeisi and Bahman Rahimi Esboei

November 2016

Antileishmanial effects of the alkaloid-rich fraction of Quassia amara L.

Control of leishmaniasis remains a challenge due the high toxicity of the chemotherapeutic drugs presently available. The ongoing search for better leishmanicidal compounds has brought herbal drugs into the limelight as safe and effective substitutes to conventional therapies which have various drawbacks. The current study was designed to evaluate the antileishmanial effect of Quassia amara against Leishmania...

Author(s): Renata S. Gabriel, Ana Claudia F. Amaral, Suzana Corte-Real, Rosana C. Lopes, Celuta S. Alviano, Alane B. Vermelho, Daniela S. Alviano and Igor A. Rodrigues

November 2016

In silico physico-chemical evaluation, anti-inflammatory and mcf-7 breast cancer cell line growth inhibition effects of trolline isolated from Mirabilis jalapa

The in silico simulations and predictions approach in evaluation of pharmacokinetic properties of new chemical entities (NCEs) is fast becoming an acceptable trend in natural products research and drug discovery. This paper focuses on the properties of trolline with respect to its anti-inflammatory and MCF-7 breast cancer cell line growth inhibition effects and an attempt to predict physico-chemical drug-like properties...

Author(s): Mas’ud Eneji Sadiq, Hajia Mairo Inuwa, Mujeeb-ur-Rehman and Khalid Ahmad