November 2020

Phytochemical screening and antimicrobial activity of methanol extract of Garcinia Kola Heckle fruit mesocarp

The phytochemical screening and antimicrobial activities of the methanol extract of Garcinia kola fruit mesocarp were investigated against four bacteria and two fungi in the study. The extract was investigated for the presence of phytochemicals using standard phytochemical screening methods. The results revealed the presence of flavonoids, tannins, alkaloids, terpenoids, cardiac glycosides, and reducing sugar. The...

Author(s): Ali Ibeabuchi Jude, Adonu Cyril Chekwube and Okorie Ndidiamaka Hannah

November 2020

Inhibitory effects of Anadenanthera colubrina (Vell.) Brenan stem bark extract on α-glucosidase activity and oxidative stress

In this study, we investigated the promising potential of Anadenanthera colubrina bark extract (BEAc) as a product to combat diabetes mellitus (DM). We evaluated the inhibitory effects of BEAc on α-glucosidase and the oxidation of biomolecules, as well as its main phytoconstituents. In terms of free radical scavenging, BEAc exhibited a dose-effect relationship. BEAc was more efficient than rutin and butylated...

Author(s): Odelio Joaquim da Costa, Robson dos Santos Barbosa, Ilsamar Mendes Soares, Eber Euripedes de Souza, Luís Fernando A. Gellen, João Pedro Pereira P. Lemos, Raimundo Wagner S. Aguiar, Adão Lincon B. Montel and Sérgio Donizeti Ascêncio  

November 2020

Lavandula angustifolia aqueous extract ameliorates anxiety and depressive-like behaviors in chronic mild stress-treated male rats

The study aims to show the possible anxiolytic and antidepressant-like properties of an oral lavender’s flower aqueous extract (LAE) in chronic mild stress (CMS) model of rats. Test and control rats received LAE (200 or 400 mg/ kg) and distilled water respectively. Tests of Sucrose preference (SP), elevated plus maze (EPM), and open field (OFT) were used to evaluate rats’ behavioral changes.  The...

Author(s): Mir Behrad Aghazadeh Ghadim, Asma Neisy, Mohsen Sisakht and Zahra Khoshdel ⃰  

November 2020

Evaluating the antibacterial, antioxidant and wound healing properties of the stem bark extract of Khaya grandifoliola (Welw) CDC (Meliaceae) (African mahogany)

The study was conducted to evaluate the antibacterial, antioxidant, and wound healing properties of the stem bark of Khaya grandifoliola (Welw) CDC (Meliaceae). A preliminary phytochemical screening conducted showed the presence of tannins, alkaloids, saponins, reducing sugars, flavonoids, terpenoids, and phenols in the stem bark (KG) as well as its ethanol extract (KGE). The antibacterial activity of KGE was evaluated...

Author(s): Anna Kwarley Quartey, Emmanuel Orman, Nana Ama Mireku-Gyimah, Phoebe Esinam Goku, Fadila Alidu and Linda Owusu Boateng  

November 2020

In vitro antioxidant and cytotoxic activity of the root extract of Aspilia mossambicensis (Oliv) Wild (Asteraceae)

Aspiliamossambicensis(Oliv) Wild is used by Traditional Health Practitioners in northeastern Tanzania, for treatment of cancers. In order to evaluate these claims root powder of the plant was extracted with dichloromethane: methanol (1:1), followed by vacuum liquid chromatography fractionation to obtain dichloromethane, ethyl acetate and methanol fractions which were screened for brine shrimp toxicity and antioxidant...

Author(s): Daniel Zacharia Matata, Olipa David Ngassapa, Mainen Julius Moshi, Francis Machumi, Kenneth Oosthuizen, Bresler Swanepoel, Luanne Venables, Trevor Koekemoer, Matthias Heydenreich, Paul Erasto Kazyoba and Maryna van de Venter